EP 2698386 B8 20180207 - FUSION PROTEIN
Title (en)
FUSION PROTEIN
Title (de)
FUSIONSPROTEIN
Title (fr)
PROTÉINE DE FUSION
Publication
Application
Priority
- JP 2011088762 A 20110413
- JP 2012058912 W 20120402
Abstract (en)
[origin: EP2698386A1] The present invention provides a new fusion protein which can specifically suppress the autoantibodies, which can effectively prevent or treat the autoimmune disease of autoantibody type, and which can be expressed in an amount sufficient for industrial production. A fusion protein, characterized in that, a protein (X) containing a site recognized by autoantibodies which are a cause of the autoimmune disease of autoantibody type is connected to a protein (A) containing a fragment of the antibody heavy chain constant region which exhibits the antibody-dependent cellular cytotoxicity with a linker peptide (L) consisting of one or more amino acid (s), wherein the protein (X), the linker peptide (L) and the protein (A) are connected in this order by means of peptide bond from N terminal to C terminal.
IPC 8 full level
A61K 38/00 (2006.01); A61P 37/06 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01)
CPC (source: EP US)
A61P 37/06 (2017.12 - EP); C07K 14/705 (2013.01 - EP US); C07K 16/42 (2013.01 - US); A61K 38/00 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US); C07K 2319/30 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 2698386 A1 20140219; EP 2698386 A4 20141203; EP 2698386 B1 20171220; EP 2698386 B8 20180207; CN 103476800 A 20131225; CN 103476800 B 20160706; ES 2655941 T3 20180222; JP 2012219082 A 20121112; JP 4857396 B1 20120118; US 2014335085 A1 20141113; US 9243071 B2 20160126; WO 2012141026 A1 20121018
DOCDB simple family (application)
EP 12770896 A 20120402; CN 201280018104 A 20120402; ES 12770896 T 20120402; JP 2011088762 A 20110413; JP 2012058912 W 20120402; US 201214110287 A 20120402