EP 2699270 A4 20141210 - ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF
Title (en)
ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF
Title (de)
ADENOASSOZIIERTE VIRUS-VIRIONEN MIT VERÄNDERLICHEM KAPSID UND VERWENDUNGSVERFAHREN DAFÜR
Title (fr)
VIRIONS DE VIRUS ADÉNO-ASSOCIÉ AVEC CAPSIDE VARIANT ET PROCÉDÉS D'UTILISATION DE CEUX-CI
Publication
Application
Priority
- US 201161478355 P 20110422
- US 2012034413 W 20120420
Abstract (en)
[origin: WO2012145601A2] The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
IPC 8 full level
A61K 48/00 (2006.01); C07K 14/005 (2006.01); C12N 15/63 (2006.01); C12N 15/86 (2006.01)
CPC (source: CN EP IL KR RU US)
A61K 9/0019 (2013.01 - IL KR US); A61K 9/0048 (2013.01 - KR US); A61K 38/1709 (2013.01 - EP IL US); A61K 48/00 (2013.01 - RU); A61K 48/0008 (2013.01 - KR US); A61K 48/0025 (2013.01 - US); A61K 48/0075 (2013.01 - CN EP KR US); A61P 3/10 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 27/00 (2018.01 - EP); A61P 27/02 (2018.01 - EP IL KR); A61P 27/06 (2018.01 - EP IL); A61P 43/00 (2018.01 - EP); C07K 14/005 (2013.01 - CN EP IL KR US); C12N 7/00 (2013.01 - IL KR US); C12N 15/113 (2013.01 - IL US); C12N 15/115 (2013.01 - US); C12N 15/86 (2013.01 - CN EP IL KR US); C12N 15/861 (2013.01 - IL); C12N 15/864 (2013.01 - RU); C12Q 1/70 (2013.01 - IL US); C12Q 1/701 (2013.01 - IL US); G01N 33/5008 (2013.01 - US); G01N 33/5058 (2013.01 - US); C07K 2319/33 (2013.01 - CN EP IL US); C12N 2310/14 (2013.01 - US); C12N 2310/16 (2013.01 - US); C12N 2320/32 (2013.01 - US); C12N 2750/14021 (2013.01 - IL US); C12N 2750/14121 (2013.01 - IL US); C12N 2750/14122 (2013.01 - CN EP IL US); C12N 2750/14142 (2013.01 - US); C12N 2750/14143 (2013.01 - IL KR US); C12N 2750/14145 (2013.01 - CN EP IL US); C12N 2750/14152 (2013.01 - IL US); C12N 2810/40 (2013.01 - CN EP IL KR US); C12Q 2600/158 (2013.01 - EP US); C12Q 2600/16 (2013.01 - US)
Citation (search report)
- [XY] WO 2010093784 A2 20100819 - UNIV NORTH CAROLINA [US], et al
- [Y] HILDA PETRS-SILVA ET AL: "High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors", MOLECULAR THERAPY, vol. 17, no. 3, March 2009 (2009-03-01), pages 463 - 471, XP055076954, ISSN: 1525-0016, DOI: 10.1038/mt.2008.269
- [Y] T K PARK ET AL: "Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse", GENE THERAPY, vol. 16, no. 7, July 2009 (2009-07-01), pages 916 - 926, XP055113217, ISSN: 0969-7128, DOI: 10.1038/gt.2009.61
- [A] ARAVIND ASOKAN ET AL: "Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle", NATURE BIOTECHNOLOGY, vol. 28, no. 1, January 2010 (2010-01-01), pages 79 - 82, XP055062283, ISSN: 1087-0156, DOI: 10.1038/nbt.1599
- See also references of WO 2012145601A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
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