EP 2711000 B1 20190403 - Targeted Liposomes
Title (en)
Targeted Liposomes
Title (de)
Gezielt ausgerichtete Liposome
Title (fr)
Liposomes ciblés
Publication
Application
Priority
US 201261702796 P 20120919
Abstract (en)
[origin: EP2711000A1] The present invention is in the field of drug delivery, and specifically, cationic liposome-based drug delivery. In embodiments, this invention provides methods of making ligand-targeted (e.g., antibody- or antibody fragment-targeted) liposomes useful for the delivery of liposomes to tumors, including brain tumors. In embodiments, the liposomes deliver temozolomide across the blood-brain barrier for treatment of primary or metastatic brain tumors. Additional cancers that can be treated with the liposomes include neuroendocrine tumors, melanoma, prostate, head and neck, ovarian, lung, liver, breast, urogenital, gastric, colorectal, cervical, liposarcoma, rhabdomyosarcoma, choriocarcinoma, pancreatic, retinoblastoma and other types of cancer. In another embodiment the liposomes deliver melphalan for the treatment of multiple myeloma, other tumors of the blood or other solid tumors. In still other embodiments the liposomes can deliver other drugs, including atropine for treatment of organophosphate poisoning.
IPC 8 full level
A61K 9/127 (2006.01); A61K 31/195 (2006.01); A61K 31/4188 (2006.01); A61K 31/46 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP KR)
A61K 9/127 (2013.01 - KR); A61K 9/1272 (2013.01 - EP); A61K 31/198 (2013.01 - EP); A61K 31/41 (2013.01 - KR); A61K 31/46 (2013.01 - EP); A61K 31/495 (2013.01 - EP); A61K 31/711 (2013.01 - EP); A61K 39/395 (2013.01 - EP KR); A61K 47/6911 (2017.07 - EP); A61K 47/6913 (2017.07 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 35/04 (2017.12 - EP); A61P 39/00 (2017.12 - EP); A61P 39/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 16/2881 (2013.01 - EP); C07K 2317/622 (2013.01 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 2711000 A1 20140326; EP 2711000 B1 20190403; AU 2013200991 A1 20140403; AU 2013200991 B2 20151210; BR 102013004109 A2 20150623; CA 2806896 A1 20140319; CA 2806896 C 20210615; CN 103655475 A 20140326; CN 103655475 B 20200428; IL 224860 A0 20130627; IL 224860 B 20190530; JP 2014062084 A 20140410; KR 20140038288 A 20140328; SG 2013014170 A 20140428; TW 201412344 A 20140401; TW I614034 B 20180211
DOCDB simple family (application)
EP 13156234 A 20130221; AU 2013200991 A 20130221; BR 102013004109 A 20130221; CA 2806896 A 20130221; CN 201310055120 A 20130221; IL 22486013 A 20130221; JP 2013031944 A 20130221; KR 20130018724 A 20130221; SG 2013014170 A 20130221; TW 102106061 A 20130221