Global Patent Index - EP 2716291 A1

EP 2716291 A1 20140409 - Combination of opioids and anticancer drugs for cancer treatment

Title (en)

Combination of opioids and anticancer drugs for cancer treatment

Title (de)

Kombination von Opioiden und Antikrebsarzneimitteln zur Krebsbehandlung

Title (fr)

Combinaison d'opioïdes et médicaments anticancéreux pour le traitement du cancer

Publication

EP 2716291 A1 20140409 (EN)

Application

EP 12007179 A 20121017

Priority

  • EP 12006946 A 20121008
  • EP 12007179 A 20121017

Abstract (en)

The invention relates to novel strategies for the treatment of cancer patients based on a combination of an opioid receptor agonist and an anticancer compound.

IPC 8 full level

A61K 31/485 (2006.01); A61K 33/243 (2019.01); A61P 35/00 (2006.01)

CPC (source: EP US)

A61K 31/137 (2013.01 - EP US); A61K 31/445 (2013.01 - EP US); A61K 31/4468 (2013.01 - EP US); A61K 31/485 (2013.01 - EP US); A61K 31/704 (2013.01 - EP US); A61K 31/7048 (2013.01 - EP US); A61K 31/7076 (2013.01 - EP US); A61K 33/24 (2013.01 - US); A61K 33/243 (2018.12 - EP US); A61K 45/06 (2013.01 - EP US); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); G01N 33/5011 (2013.01 - EP US); G01N 33/5014 (2013.01 - US); G01N 2500/04 (2013.01 - US)

C-Set (source: EP US)

  1. A61K 31/137 + A61K 2300/00
  2. A61K 31/704 + A61K 2300/00
  3. A61K 33/24 + A61K 2300/00
  4. A61K 31/7048 + A61K 2300/00
  5. A61K 31/7076 + A61K 2300/00
  6. A61K 31/4468 + A61K 2300/00
  7. A61K 31/485 + A61K 2300/00

Citation (applicant)

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  • BERGMANN JP; HARRIS D.: "Radioresistance, chemoresistance and apoptosis resistance", RADIATION ONCOLOGY, vol. 27, 1997, pages 47 - 57
  • "Pathologie", 2008, ELSEVIER, article "Tumorerkrankungen"
  • BORGMANN, A.; BALDY, C.; VON STACKELBERG, A.; BEYERMANN, B.; FICHTNER, I.; NURNBERG, P.; HENZE, G.: "Childhood all blasts retain phenotypic and genotypic characteristics upon long-term serial passage in NOD/SCID mice", PEDIATR HEMATOL ONCOL, vol. 17, 2000, pages 635 - 650
  • CARBONARI M; CIBATI M; CHERCHI M ET AL.: "Detection and characterization of apoptotic peripheral blood lymphocytes in human immunodeficiency virus-infection and cancer chemotherapy by a novel flow immunocytometric method", BLOOD, vol. 83, 1994, pages 1268 - 77
  • CLASSEN, C. F.; FALK, C. S.; FRIESEN, C.; FULDA, S.; HERR, I.; DEBATIN, K. M.: "Natural killer resistance of a drug-resistant leukemia cell line, mediated by up-regulation of HLA class I expression", HAEMATOLOGICA, vol. 88, 2003, pages 509 - 521
  • CRETTOL, S.; DIGON, P.; GOLAY, K. P.; BRAWAND, M.; EAP, C. B.: "In vitro P-glycoprotein-mediated transport of (R)-, (S)-, (R,S)-methadone, LAAM and their main metabolites", PHARMACOLOGY, vol. 80, 2007, pages 304 - 311
  • DIESTRA, J. E.; CONDOM, E.; DEL MURO, X. G.; SCHEFFER, G. L.; PEREZ, J.; ZURITA, A. J.; MUNOZ-SEGUI, J.; VIGUES, F.; SCHEPER, R. J: "Expression of multidrug resistance proteins P-glycoprotein, multidrug resistance protein 1, breast cancer resistance protein and lung resistance related protein in locally advanced bladder cancer treated with neoadjuvant chemotherapy: biological and clinical implications", J UROL, vol. 170, 2003, pages 1383 - 1387, XP005533308, DOI: doi:10.1097/01.ju.0000074710.96154.c9
  • FRIESEN C; GLATTING G; KOOP B ET AL.: "Breaking chemo- and radioresistance with [21 'Bi]anti-CD45 antibodies in leukaemia cells", CANCER RES, vol. 67, no. 5, 2007, pages 1950 - 8
  • FRIESEN C; KIESS Y; DEBATIN KM.: "A critical role of glutathione in determining apoptosis sensitivity and resistance in leukaemia cells", CELL DEATH DIFFER, vol. 11, no. 1, 2004, pages 73 - 85
  • FULDA, S.: "Cell death in hematological tumors", APOPTOSIS, vol. 14, 2009, pages 409 - 423, XP019669508
  • FULDA, S.: "Therapeutic opportunities for counteracting apoptosis resistance in childhood leukaemia", BR J HAEMATOL, vol. 145, 2009, pages 441 - 454
  • FULDA, S.: "Tumor resistance to apoptosis", INT J CANCER, vol. 124, 2009, pages 511 - 515
  • HILGER, R. A.; RICHLY, H.; GRUBERT, M.; OBERHOFF, C.; STRUMBERG, D.; SCHEULEN, M. E.; SEEBER, S.: "Pharmacokinetics (PK) of a liposomal encapsulated fraction containing doxorubicin and of doxorubicin released from the liposomal capsule after intravenous infusion of Caelyx/Doxil", INT J CLIN PHARMACOL THER, vol. 43, 2005, pages 588 - 589
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  • POSOVSZKY, C.; FRIESEN, C.; HERR, I.; DEBATIN, K. M.: "Chemotherapeutic drugs sensitize pre-B ALL cells for CD95- and cytotoxic T-lymphocyte-mediated apoptosis", LEUKEMIA, vol. 13, 1999, pages 400 - 409, XP001182234, DOI: doi:10.1038/sj/leu/2401327
  • RICHLY, H.; HENNING, B. F.; KUPSCH, P.; PASSARGE, K.; GRUBERT, M.; HILGER, R. A.; CHRISTENSEN, O.; BRENDEL, E.; SCHWARTZ, B.; LUDW: "Results of a Phase I trial of sorafenib (BAY 43-9006) in combination with doxorubicin in patients with refractory solid tumors", ANN ONCOL, vol. 17, 2006, pages 866 - 873, XP002520236, DOI: doi:10.1093/ANNONC/MDL017
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  • WORKMAN, P.; ABOAGYE, E. O.; BALKWILL, F.; BALMAIN, A.; BRUDER, G.; CHAPLIN, D. J.; DOUBLE, J. A.; EVERITT, J.; FARNINGHAM, D. A.;: "Guidelines for the welfare and use of animals in cancer research", BR J CANCER, vol. 102, 2010, pages 1555 - 1577

Citation (search report)

[X] EP 2149372 A1 20100203 - UNIV ULM [DE]

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 2716291 A1 20140409; EP 2716291 B1 20191127; BR 112015007866 A2 20170808; CA 2887043 A1 20140417; CA 2887043 C 20210622; CN 104902897 A 20150909; DK 2716291 T3 20200302; ES 2779223 T3 20200814; JP 2015532298 A 20151109; JP 6472750 B2 20190220; PL 2716291 T3 20200615; PT 2716291 T 20200304; RU 2015114786 A 20161127; US 11052082 B2 20210706; US 2015265594 A1 20150924; US 2018280380 A1 20181004; WO 2014056897 A1 20140417

DOCDB simple family (application)

EP 12007179 A 20121017; BR 112015007866 A 20131008; CA 2887043 A 20131008; CN 201380060492 A 20131008; DK 12007179 T 20121017; EP 2013070923 W 20131008; ES 12007179 T 20121017; JP 2015535060 A 20131008; PL 12007179 T 20121017; PT 12007179 T 20121017; RU 2015114786 A 20131008; US 201314434138 A 20131008; US 201816000467 A 20180605