Global Patent Index - EP 2723354 B1

EP 2723354 B1 20200527 - COMPOSITIONS, USES, AND PREPARATION OF PLATELET LYSATES

Title (en)

COMPOSITIONS, USES, AND PREPARATION OF PLATELET LYSATES

Title (de)

ZUSAMMENSETZUNGEN, VERWENDUNGEN UND HERSTELLUNG VON THROMBOZYTENLYSATEN

Title (fr)

COMPOSITIONS, UTILISATIONS ET PRÉPARATION DE LYSATS DE PLAQUETTES

Publication

EP 2723354 B1 20200527 (EN)

Application

EP 12804449 A 20120626

Priority

  • US 201161501411 P 20110627
  • US 201161547897 P 20111017
  • US 2012044211 W 20120626

Abstract (en)

[origin: WO2013003356A1] In certain embodiments, this disclosure describes compositions comprising platelet lysates depleted of fibrinogen. In a further embodiment, the composition further comprises a cell culture medium component. This disclosure also provides a method for preparing the composition, comprising the steps of (a) lysing platelets providing a lysate; (b) removing cell debris; and (c) depleting fibrinogen by forming a removable mass by adding a metal salt such as calcium chloride. Furthermore, the disclosure also describes the product produced using said method.

IPC 8 full level

A61K 35/14 (2015.01); A61K 35/19 (2015.01); A61K 38/17 (2006.01); A61P 17/02 (2006.01); A61P 27/02 (2006.01); C12N 5/071 (2010.01)

CPC (source: EP US)

A61K 31/727 (2013.01 - EP US); A61K 35/19 (2013.01 - EP US); A61K 38/1858 (2013.01 - EP US); A61L 15/40 (2013.01 - EP US); A61L 15/44 (2013.01 - EP US); A61L 17/005 (2013.01 - EP US); A61L 24/0005 (2013.01 - EP US); A61L 24/0015 (2013.01 - EP US); A61P 17/02 (2017.12 - EP); A61P 27/02 (2017.12 - EP); C12N 5/0018 (2013.01 - EP US); C12N 5/0662 (2013.01 - EP US); C12N 5/0663 (2013.01 - EP US); C12N 5/0664 (2013.01 - EP US); C12N 5/0665 (2013.01 - EP US); C12N 5/0666 (2013.01 - EP US); C12N 5/0667 (2013.01 - EP US); C12N 5/0668 (2013.01 - EP US); A61L 2300/406 (2013.01 - EP US); A61L 2300/42 (2013.01 - US); C12N 2502/115 (2013.01 - EP US)

Citation (opposition)

Opponent : Frank Piller

  • US 5198357 A 19930330 - HOLMOVIST OLOV [SE], et al
  • US 2012156306 A1 20120621 - WEISSMAN LIOR [IL], et al
  • WO 2009155069 A1 20091223 - MISHRA ALLAN [US]
  • C.H. HELDIN ET AL.: "Partial purification and characterization of platelet factors stimulating the multiplication of normal human glial cells", EXP CELL RES, vol. 109, 1977, pages 429 - 437, XP024858809, DOI: 10.1016/0014-4827(77)90023-4
  • D. L. HWANG ET AL.: "Release of different fractions of epidermal growth factor from human platelets in vitro: preferential release of 140 kDa fraction", REGULATORY PEPTIDES, vol. 37, 1992, pages 95 - 100, XP025220967, DOI: 10.1016/0167-0115(92)90658-H
  • YE CHIN CHOI ET AL.: "Effect of platelet lysate on growth and sulfated glycosaminoglycan synthesis in articular chondrocyte cultures", ARTHRITIS & RHEUMATISM, vol. 22, no. 2, February 1980 (1980-02-01), pages 220 - 224, XP055276221, DOI: 10.1002/art.1780230213
  • TANG ET AL.: "Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3p phosphorylation", J. EXP. MED., vol. 207, no. 4, 2010, pages 867 - 880, XP055979117
  • Y. HARA ET AL.: "Platelets as a Source of Growth-promoting Factor(s) for Tumor Cells", CANCER RESEARCH, vol. 40, April 1980 (1980-04-01), pages 1212 - 1216, XP055275304
  • ANONYMOUS: "Shorter Oxford English Dictionary fifth edition", 2002, article "Ophtomalogy", pages: 2007, XP055979128

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2013003356 A1 20130103; AU 2012275562 A1 20140123; AU 2012275562 B2 20161020; CA 2840568 A1 20130103; CA 2840568 C 20210504; CN 103702674 A 20140402; CN 103702674 B 20180529; CN 108671224 A 20181019; CN 108671224 B 20221213; EP 2723354 A1 20140430; EP 2723354 A4 20150311; EP 2723354 B1 20200527; EP 2723354 B3 20210324; ES 2811085 T3 20210310; ES 2811085 T7 20211129; JP 2014522833 A 20140908; JP 6179955 B2 20170816; US 2014127314 A1 20140508; US 2017304365 A1 20171026; US 9688959 B2 20170627

DOCDB simple family (application)

US 2012044211 W 20120626; AU 2012275562 A 20120626; CA 2840568 A 20120626; CN 201280036793 A 20120626; CN 201810498785 A 20120626; EP 12804449 A 20120626; ES 12804449 T 20120626; JP 2014518918 A 20120626; US 201214129448 A 20120626; US 201715607123 A 20170526