EP 2725036 B1 20171025 - Recombinant anti-epidermal growth factor receptor antibody compositions
Title (en)
Recombinant anti-epidermal growth factor receptor antibody compositions
Title (de)
Zusammensetzungen rekombinanter Antikörper gegen den Rezeptor des epidermalen Wachstumsfaktors
Title (fr)
Compositions d'anticorps recombinants dirigés contre le récepteur du facteur de croissance épidermique
Publication
Application
Priority
- DK PA200700317 A 20070301
- US 90477307 P 20070305
- DK PA200701016 A 20070710
- US 92972707 P 20070711
- EP 08706941 A 20080227
Abstract (en)
[origin: WO2008104183A2] The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides compositions or mixtures of antibodies capable of binding human EGFR. Antibody compositions with 3 or more antibodies have shown synergy in reduction of proliferation of representative cancer cell lines. Advantageous results have also been obtained with a composition comprising two different chimeric anti-hEGFR antibodies which show a new mechanism of action based on rapid and efficient receptor internalisation, induction of terminal differentiation and subsequent tumour eradication in an animal model. The antibodies of the invention can be manufactured in one bioreactor as a polyclonal antibody.
IPC 8 full level
C07K 16/28 (2006.01); A61K 39/395 (2006.01); C07K 14/71 (2006.01)
CPC (source: EP KR US)
A61K 39/395 (2013.01 - KR); A61K 39/39558 (2013.01 - EP US); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/71 (2013.01 - EP KR US); C07K 16/28 (2013.01 - KR); C07K 16/2863 (2013.01 - EP US); G01N 33/53 (2013.01 - KR); A61K 2039/507 (2013.01 - EP US); C07K 2317/31 (2013.01 - EP US); C07K 2317/54 (2013.01 - EP US); C07K 2317/565 (2013.01 - EP US); C07K 2317/92 (2013.01 - EP US)
Citation (examination)
- KOEFOED KLAUS ET AL: "Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor.", MABS, vol. 3, no. 6, November 2011 (2011-11-01), pages 584 - 595, ISSN: 1942-0870
- CLARA MONTAGUT ET AL: "Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer", NATURE MEDICINE, vol. 18, no. 2, 22 January 2012 (2012-01-22), pages 221 - 223, XP055103945, ISSN: 1078-8956, DOI: 10.1038/nm.2609
- BERTOTTI ANDREA ET AL: "The genomic landscape of response to EGFR blockade in colorectal cancer.", NATURE 08 OCT 2015, vol. 526, no. 7572, 8 October 2015 (2015-10-08), pages 263 - 267, ISSN: 1476-4687
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008104183 A2 20080904; WO 2008104183 A3 20081113; AU 2008221118 A1 20080904; AU 2008221118 B2 20131003; BR PI0808551 A2 20140819; BR PI0808551 B1 20220405; CA 2676049 A1 20080904; CA 2676049 C 20180410; CN 101675075 A 20100317; CN 101675075 B 20140618; CN 104151430 A 20141119; DK 2132229 T3 20160620; EP 2132229 A2 20091216; EP 2132229 B1 20160511; EP 2725036 A1 20140430; EP 2725036 B1 20171025; ES 2582386 T3 20160912; HK 1134826 A1 20100611; HK 1197252 A1 20150109; IL 199725 A0 20100415; IL 199725 A 20150630; IL 216850 A0 20120131; IL 216850 A 20140630; JP 2010535012 A 20101118; JP 5726417 B2 20150603; KR 101676622 B1 20161117; KR 101805140 B1 20171205; KR 20100014722 A 20100210; KR 20160132132 A 20161116; MX 2009008909 A 20090828; MX 338151 B 20160405; NZ 578943 A 20120928; NZ 597466 A 20130830; PL 2132229 T3 20161230; RU 2013119724 A 20141110; TW 200902552 A 20090116; TW I426083 B 20140211; US 2009004192 A1 20090101; US 2011129855 A1 20110602; US 2011135636 A1 20110609; US 7887805 B2 20110215; US 8414896 B2 20130409
DOCDB simple family (application)
DK 2008050047 W 20080227; AU 2008221118 A 20080227; BR PI0808551 A 20080227; CA 2676049 A 20080227; CN 200880006835 A 20080227; CN 201410211600 A 20080227; DK 08706941 T 20080227; EP 08706941 A 20080227; EP 13187455 A 20080227; ES 08706941 T 20080227; HK 10101608 A 20100212; HK 14110853 A 20141029; IL 19972509 A 20090707; IL 21685011 A 20111208; JP 2009551102 A 20080227; KR 20097020519 A 20080227; KR 20167031076 A 20080227; MX 2009008909 A 20080227; MX 2011011163 A 20080227; NZ 57894308 A 20080227; NZ 59746608 A 20080227; PL 08706941 T 20080227; RU 2013119724 A 20130426; TW 97107005 A 20080229; US 7405608 A 20080229; US 94549510 A 20101112; US 94552710 A 20101112