EP 2729487 A2 20140514 - NOVEL SDF-1-BASED GLYCOSAMINOGLYCAN ANTAGONIST AND METHODS OF USING SAME
Title (en)
NOVEL SDF-1-BASED GLYCOSAMINOGLYCAN ANTAGONIST AND METHODS OF USING SAME
Title (de)
NEUARTIGE SDF-1-BASIERTER GLYCOSAMINOGLYCAN-ANTAGONIST UND VERFAHREN ZU IHRER VERWENDUNG
Title (fr)
NOUVEL ANTAGONISTE DE GLYCOSAMINOGLYCANE À BASE DE SDF-1 ET SES MÉTHODES D'UTILISATION
Publication
Application
Priority
- EP 11173228 A 20110708
- EP 2012063438 W 20120709
- EP 12733152 A 20120709
Abstract (en)
[origin: WO2013007704A2] The present invention relates to novel SDF-1 mutant polypeptides with increased GAG binding affinity and reduced GPCR activity compared to wild type SDF-1 protein wherein said SDF-1 polypeptide is modified in a structure-conserving way by replacing glutamine at position 60 by a basic or electron donating amino acid and by replacing at least one additional amino acid at position 29, 39, 49, 67 and/or 68 according to the numbering of SEQ ID NO 1 by at least one basic and/or electron donating amino acid and wherein at least one amino acid of the first 1 to 10 amino acids of the N-terminal region of the wild type SDF-1 polypeptide is modified by addition, deletion and/or replacement of at least one amino acid and methods for producing these mutants and to their use for preparing medicaments for the treatment of cancer.
IPC 8 full level
C07K 14/00 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07K 14/522 (2013.01); A61K 38/195 (2013.01)
Citation (search report)
See references of WO 2013007704A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2013007704 A2 20130117; WO 2013007704 A3 20130307; EP 2729487 A2 20140514
DOCDB simple family (application)
EP 2012063438 W 20120709; EP 12733152 A 20120709