EP 2736536 A4 20150311 - TEMPLATED ISLET CELLS AND SMALL ISLET CELL CLUSTERS FOR DIABETES TREATMENT
Title (en)
TEMPLATED ISLET CELLS AND SMALL ISLET CELL CLUSTERS FOR DIABETES TREATMENT
Title (de)
TEMPLATE-INSELZELLEN UND KLEINE INSELZELLCLUSTER ZUR BEHANDLUNG VON DIABETES
Title (fr)
CELLULES D'ÎLOT SUR MATRICE ET PETITS AGRÉGATS DE CELLULES D'ÎLOT POUR LE TRAITEMENT DU DIABÈTE
Publication
Application
Priority
- US 201161512303 P 20110727
- US 201213482671 A 20120529
- US 2012048352 W 20120726
Abstract (en)
[origin: WO2013016544A2] Substrates and devices for culturing cells are disclosed, along with methods of using the same. The substrates and devices include top surfaces with one or more divots disposed therein. Each divot is defined by an opening in the top surface, a rounded bottom surface spaced from the opening, and an interior side-wall surface extending between the rounded bottom surface and the opening. The top surface of the substrates and devices are optionally walled to form wells containing one or more divots. The substrates and devices may be used for reaggregating cells, for example, to form small islet cell clusters and for high throughput testing methodologies.
IPC 8 full level
A61K 47/48 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 47/30 (2006.01); A61P 3/10 (2006.01); C12N 5/071 (2010.01)
CPC (source: EP)
A61P 3/10 (2018.01); C12N 5/0677 (2013.01); G01N 33/507 (2013.01); G01N 33/5082 (2013.01); C12N 2533/12 (2013.01); C12N 2533/40 (2013.01); C12N 2533/72 (2013.01); C12N 2535/00 (2013.01)
Citation (search report)
- [X] WO 2007087402 A2 20070802 - UNIV BROWN [US], et al
- [XPI] WO 2011126921 A2 20111013 - UNIV KANSAS [US], et al
- [A] EP 2286822 A1 20110223 - UNIV TWENTE [NL], et al
- [X] CHOI Y Y ET AL: "Controlled-size embryoid body formation in concave microwell arrays", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 31, no. 15, 1 May 2010 (2010-05-01), pages 4296 - 4303, XP026971506, ISSN: 0142-9612, [retrieved on 20100305]
- [XP] JIN WOOK HWANG ET AL: "Functional clustering of pancreatic islet cells using concave microwell array", MACROMOLECULAR RESEARCH, vol. 19, no. 12, 3 November 2011 (2011-11-03), pages 1320 - 1326, XP055164708, ISSN: 1598-5032, DOI: 10.1007/s13233-012-1202-4
- [XP] HWANG JIN WOOK ET AL: "Optimal size control of pancreatic islet cell clusters using concave-bottomed microwells.", JOURNAL OF CONTROLLED RELEASE : OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY 30 NOV 2011, vol. 152 Suppl 1, 30 November 2011 (2011-11-30), pages e218 - e219, XP002734971, ISSN: 1873-4995
- [A] ALDERT H. PIERSMA: "Alternative Methods for Developmental Toxicity Testing", BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, vol. 98, no. 5, 1 May 2006 (2006-05-01), pages 427 - 431, XP055164713, ISSN: 1742-7835, DOI: 10.1111/j.1742-7843.2006.pto_373.x
- [T] KARTHIK RAMACHANDRAN ET AL: "Engineering Islets for Improved Performance by Optimized Reaggregation in a Micromold", TISSUE ENGINEERING PART A, vol. 19, no. 5-6, 1 March 2013 (2013-03-01), pages 604 - 612, XP055164716, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2012.0553
Citation (examination)
KUNZ-SCHUGHART L A ET AL: "The use of 3-D cultures for high-throughput screening: The multicellular spheroid model", JOURNAL OF BIOMOLECULAR SCREENING, SAGE; LIEBERT, US, vol. 9, no. 4, 1 June 2004 (2004-06-01), pages 273 - 285, XP002694233, ISSN: 1087-0571, DOI: 10.1177/1087057104265040
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2013016544 A2 20130131; WO 2013016544 A3 20130425; WO 2013016544 A4 20130613; CA 2842695 A1 20130131; CA 2842695 C 20210112; EP 2736536 A2 20140604; EP 2736536 A4 20150311; EP 3498300 A1 20190619; JP 2014521335 A 20140828
DOCDB simple family (application)
US 2012048352 W 20120726; CA 2842695 A 20120726; EP 12818108 A 20120726; EP 18186206 A 20120726; JP 2014523006 A 20120726