Global Patent Index - EP 2737895 A1

EP 2737895 A1 20140604 - Microparticles with EGF, method of preparation and use

Title (en)

Microparticles with EGF, method of preparation and use

Title (de)

Mikropartikel mit EGF, Herstellungsverfahren und Verwendung

Title (fr)

Microparticules avec EGF, procédé de préparation et d'utilisation

Publication

EP 2737895 A1 20140604 (EN)

Application

EP 12382476 A 20121130

Priority

EP 12382476 A 20121130

Abstract (en)

The present invention relates to microparticles comprising biocompatible polymers and epidermal growth factor. The present invention also relates to the method of preparing said microparticles and to their use in promoting wound healing.

IPC 8 full level

A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 9/16 (2006.01); A61K 38/18 (2006.01); A61K 47/42 (2006.01); C07K 14/485 (2006.01)

CPC (source: EP ES)

A61K 9/0014 (2013.01 - EP); A61K 9/0019 (2013.01 - EP); A61K 9/06 (2013.01 - EP); A61K 9/1647 (2013.01 - EP); A61K 9/1652 (2013.01 - EP); A61K 9/50 (2013.01 - ES); A61K 38/1808 (2013.01 - EP ES); A61K 47/42 (2013.01 - EP); C07K 14/485 (2013.01 - EP ES)

Citation (applicant)

  • WO 2007087759 A2 20070809 - CT INGENIERIA GENETICA BIOTECH [CU], et al
  • WO 9118999 A1 19911212 - LEVIN ROBERT H [US], et al
  • GOLDMAN R: "Growth factors and chronic wound healing: past, present and future", ADV SKIN WOUND CARE, vol. 17, 2004, pages 24 - 35
  • CHU ET AL.: "Nanotechnology promotes the full-thickness diabetic wound healing effect of recombinant human epidermal growth factor in diabetic rats", WOUND REPAIR REGEN, vol. 15, 2010, pages 499 - 505, XP055059264, DOI: doi:10.1111/j.1524-475X.2010.00612.x
  • MARIOKA-FUJIMOTO: "Modified enterotoxin signal sequences increase secretion level of the recombinant human epidermal growth factor in Escherichia coli", J BIOL CHEM., vol. 266, no. 3, 25 January 1991 (1991-01-25), pages 1728 - 32, XP002006626
  • IGARTUA ET AL.: "y-Irradiation effects on biopharmaceutical properties of PLGA microspheres loaded with SPf66 synthetic vaccine", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 69, no. 2, 2008, pages 519 - 526, XP022664266, DOI: doi:10.1016/j.ejpb.2007.12.014
  • PURAS ET AL.: "Encapsulation of A?1-15 in PLGA microparticles enhances serum antibody response in mice immunized by subcutaneous and intranasal routes", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 44, no. 3, 2011, pages 200 - 206, XP028309882, DOI: doi:10.1016/j.ejps.2011.07.010
  • TAYLOR; FANCIS, PARTICLE SIZE ANALYSIS IN PHARMACEUTICS AND OTHER INDUSTRIES: THEORY AND PRACTICE, 1992
  • MALVERN INSTRUMENTS USER MANUAL, 2009
  • SALVADOR: "Combination of immune stimulating adjuvants with poly(lactide-co-glycolide", VACCINE, vol. 30, no. 3, 2012, pages 589 - 596, XP028348171, DOI: doi:10.1016/j.vaccine.2011.11.057
  • "Human EGF Elisa development kit protocol", PEPROTECH, 2011
  • ZHOU: "Effects of Leukemia Inhibitory Factor on Proliferation and Odontoblastic Differentiation of Human Dental Pulp Cells", J ENDOD, vol. 37, no. 6, June 2011 (2011-06-01), pages 819 - 824
  • WALTERA ET AL.: "Mesenchymal stem cell-conditioned medium accelerates skin wound healing: An in vitro study of fibroblast and keratinocyte scratch assays", EXPERIMENTAL CELL RESEARCH, vol. 316, 2010, pages 1271 - 1281, XP055192472, DOI: doi:10.1016/j.yexcr.2010.02.026
  • LI: "Research of PDGF-BB Gel on the Wound Healing of Diabetic Rats and Its Pharmacodynamics.", J SURG RES, vol. 145, no. 1, 3 December 2007 (2007-12-03), pages 41 - 8, XP022478041, DOI: doi:10.1016/j.jss.2007.02.044
  • "Quantitative and reproducible murine model of excisional wound healing", WOUND REPAIR AND REGENERATION, vol. 12, no. 4, 2004, pages 485 - 492
  • SINHA: "Effects of steel scalpel, ultrasonic scalpel, C02 laser, and monopolar and bipolar electrosurgery on wound healing in guinea pig oral mucosa", LARYNGOSCOPE, vol. 113, no. 2, 2003, pages 228 - 236

Citation (search report)

  • [XI] CN 1720989 A 20060118 - SHENZHEN TSINGHUA YUANXING BIO [CN]
  • [I] EP 2075004 A1 20090701 - CT INGENIERIA GENETICA BIOTECH [CU]
  • [ID] EP 1987817 A2 20081105 - CT INGENIERIA GENETICA BIOTECH [CU]
  • [A] DOWNS E C ET AL: "CALCIUM ALGINATE BEADS AS A SLOW-RELEASE SYSTEM FOR DELIVERING ANGIOGENIC MOLECULES IN VIVO AND IN VITRO", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY SUBSCRIPTION SERVICES, INC, vol. 152, no. 2, 1 August 1992 (1992-08-01), pages 422 - 429, XP002072808, ISSN: 0021-9541, DOI: 10.1002/JCP.1041520225
  • [A] FERNANDEZ-MONTEQUIN J I ET AL: "Intralesional administration of epidermal growth factor-based formulation (Heberprot-P) in chronic diabetic foot ulcer: Treatment up to complete wound closure", INTERNATIONAL WOUND JOURNAL, BLACKWELL PUBLISHING LTD, UK, vol. 6, no. 1, 1 February 2009 (2009-02-01), pages 67 - 72, XP009143739, ISSN: 1742-4801, DOI: 10.1111/J.1742-481X.2008.00561.X

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 2737895 A1 20140604; ES 2540453 A2 20150709; ES 2540453 B1 20160907; ES 2540453 R1 20160223; WO 2014083233 A1 20140605

DOCDB simple family (application)

EP 12382476 A 20121130; ES 2013070833 W 20131202; ES 201590050 A 20131202