Global Patent Index - EP 2752487 A1

EP 2752487 A1 20140709 - Intracellular phenotypic screening

Title (en)

Intracellular phenotypic screening

Title (de)

Intrazelluläres Phänotypen-Screening

Title (fr)

Criblage phénotypique intracellulaire

Publication

EP 2752487 A1 20140709 (EN)

Application

EP 13305003 A 20130103

Priority

EP 13305003 A 20130103

Abstract (en)

The present invention relates to a method for identifying a cellular target involved in a cell phenotype comprising identifying an intrabody which can modify a cell phenotype and identifying a direct or indirect cellular target of the intrabody. The present invention also relates to intrabodies 3H2-1, 3H2-VH and 5H4 which are capable of inhibiting the degranulation reaction in mast cells triggered by an allergic stimulus, and especially to intrabodies 3H2-1 and 5H4 which are capable of directly or indirectly targeting a protein of the ABCF1 family and of the C12ORF4 family respectively. The present invention also relates to ABCF1 and C12ORF4 inhibitors for use in therapy, in particular for treating allergic and/or inflammatory conditions.

IPC 8 full level

C12N 15/10 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01)

CPC (source: EP US)

C07K 16/00 (2013.01 - EP US); C07K 16/18 (2013.01 - US); G01N 33/5008 (2013.01 - EP US); G01N 33/5023 (2013.01 - US); G01N 33/6845 (2013.01 - EP US); G01N 33/6854 (2013.01 - EP US); C07K 2317/565 (2013.01 - US); C07K 2317/622 (2013.01 - EP US); C07K 2317/80 (2013.01 - EP US); G01N 2500/02 (2013.01 - US); G01N 2500/10 (2013.01 - US)

Citation (applicant)

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Citation (search report)

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 2752487 A1 20140709; AU 2014204299 A1 20150730; CA 2896972 A1 20140710; CN 105358689 A 20160224; EP 2941486 A1 20151111; MX 2015008726 A 20160630; SG 11201505216V A 20150828; US 2015346192 A1 20151203; WO 2014106639 A1 20140710

DOCDB simple family (application)

EP 13305003 A 20130103; AU 2014204299 A 20140102; CA 2896972 A 20140102; CN 201480012115 A 20140102; EP 14700037 A 20140102; EP 2014050032 W 20140102; MX 2015008726 A 20140102; SG 11201505216V A 20140102; US 201414759193 A 20140102