EP 2753638 A1 20140716 - PROCESS FOR THE SYNTHESIS OF TELAVANCIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS AS WELL AS N-PROTECTED DERIVATIVES THEREOF
Title (en)
PROCESS FOR THE SYNTHESIS OF TELAVANCIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS AS WELL AS N-PROTECTED DERIVATIVES THEREOF
Title (de)
VERFAHREN ZUR SYNTHESE VON TELAVANCIN UND DESSEN PHARMAZEUTISCH VERTRÄGLICHE SALZE SOWIE N-GESCHÜTZTE DERIVATE DAVON
Title (fr)
PROCÉDÉ POUR LA SYNTHÈSE DE LA TÉLAVANCINE ET DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES AINSI QUE DE SES DÉRIVÉS N-PROTÉGÉS
Publication
Application
Priority
- EP 11180721 A 20110909
- EP 2012067490 W 20120907
- EP 12759086 A 20120907
Abstract (en)
[origin: WO2013034675A1] The invention relates to a process for the preparation of telavancin, or a pharmaceutically acceptable salt thereof, wherein said process comprises a reductive alkylation of vancomycin which provides N-protected-decylaminoethylvancomycin, followed by aminomethyiation to obtain N-protected-telavancin, which is then deprotected to provide telavancin, or a pharmaceutically acceptable salt thereof. Another embodiment refers to N-protected-telavancin and pharmaceutically acceptable salts thereof, which are formed during the process of the invention.
IPC 8 full level
C07K 9/00 (2006.01)
CPC (source: EP)
C07K 9/008 (2013.01)
Citation (search report)
See references of WO 2013034675A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
DOCDB simple family (application)
EP 2012067490 W 20120907; EP 12759086 A 20120907