Global Patent Index - EP 2753641 A4

EP 2753641 A4 20150624 - NEUROPROTECTIVE CELL-PENETRATING PEPTIDES

Title (en)

NEUROPROTECTIVE CELL-PENETRATING PEPTIDES

Title (de)

NEUROPROTEKTIVE ZELLPENETRIERENDE PEPTIDE

Title (fr)

PEPTIDES DE PÉNÉTRATION CELLULAIRE NEUROPROTECTEURS

Publication

EP 2753641 A4 20150624 (EN)

Application

EP 12830062 A 20120905

Priority

  • FI 20115870 A 20110905
  • FI 2012050859 W 20120905

Abstract (en)

[origin: WO2013034805A1] The present invention relates to the fields of bioactive peptides and cell-penetrating peptides as well as to the field of neurotrophic factors, i.e. growth factors for neural cells. The present invention provides peptides with length of 4 to 40 amino acids comprising the sequence CKGC (SEQ ID NO:1 ) or CRAC (SEQ ID NO:2). Pharmaceutical compositions comprising said peptides are also provided as well as the peptides for use in the treatment of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, stroke, peripheral neuropathy, epilepsy, diabetes or drug addiction. The invention is also directed to a method for promoting survival of dopaminergic neurons. In addition, peptides with length of 4 to 40 amino acids comprising the sequence CXXC (SEQ ID NO: 5) for use in the above mentioned diseases are also provided.

IPC 8 full level

C07K 14/475 (2006.01); A61K 38/07 (2006.01); A61K 38/18 (2006.01); A61P 5/00 (2006.01); A61P 25/00 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); C07K 5/103 (2006.01)

CPC (source: EP)

A61K 38/07 (2013.01); A61P 5/00 (2017.12); A61P 25/00 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); A61P 25/30 (2017.12); C07K 5/1013 (2013.01); C07K 14/475 (2013.01)

Citation (search report)

  • [I] WO 02074956 A2 20020926 - PRESCIENT NEUROPHARMA INC [CA], et al
  • [I] WO 2009133247 A1 20091105 - LICENTIA OY [FI], et al
  • [X] WO 2004050688 A1 20040617 - XENOME LTD [AU], et al
  • [X] US 2003109457 A1 20030612 - ATLAS DAPHNE [IL]
  • [X] WO 02079246 A2 20021010 - GENEPROT INC [CH], et al
  • [X] US 2003109690 A1 20030612 - RUBEN STEVEN M [US], et al & DATABASE REGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 12 June 2003 (2003-06-12), Database accession no. 536071-66-6
  • [A] WO 9943693 A1 19990902 - HUMAN GENOME SCIENCES INC [US], et al
  • [I] VICTOR J. HRUBY: "Designing peptide receptor agonists and antagonists", NATURE REVIEWS DRUG DISCOVERY, vol. 1, no. 11, 1 November 2002 (2002-11-01), pages 847 - 858, XP055034286, ISSN: 1474-1776, DOI: 10.1038/nrd939
  • [X] JORDAN M. FLETCHER ET AL: "Novel monocyclic and bicyclic loop mimetics of brain-derived neurotrophic factor", JOURNAL OF PEPTIDE SCIENCE, vol. 12, no. 8, 1 January 2006 (2006-01-01), pages 515 - 524, XP055145298, ISSN: 1075-2617, DOI: 10.1002/psc.760
  • [A] M. HELLMAN: "Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons", J. BIOL. CHEM., vol. 286, no. 4, 1 January 2011 (2011-01-01), pages 2675 - 2680, XP055145300
  • [A] PÄIVI LINDHOLM ET AL: "Novel CDNF/MANF family of neurotrophic factors", DEVELOPMENTAL NEUROBIOLOGY, 1 January 2010 (2010-01-01), pages NA - NA, XP055145301, ISSN: 1932-8451, DOI: 10.1002/dneu.20760
  • See references of WO 2013034805A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2013034805 A1 20130314; EP 2753641 A1 20140716; EP 2753641 A4 20150624; FI 20115870 A0 20110905

DOCDB simple family (application)

FI 2012050859 W 20120905; EP 12830062 A 20120905; FI 20115870 A 20110905