EP 2758438 A1 20140730 - BISPECIFIC BINDING MOLECULES FOR 5T4 AND CD3
Title (en)
BISPECIFIC BINDING MOLECULES FOR 5T4 AND CD3
Title (de)
BISPEZIFISCHE BINDENDE MOLEKÜLE FÜR 5T4 UND CD3
Title (fr)
MOLÉCULES DE LIAISON BISPÉCIFIQUES POUR 5T4 ET CD3
Publication
Application
Priority
- US 201161538716 P 20110923
- EP 2012068673 W 20120921
Abstract (en)
[origin: WO2013041687A1] The present invention provides a bispecific binding molecule comprising a first and a second binding domain wherein the first binding domain is capable of binding to the epitope cluster 4 of T4 and the second binding domain is capable of binding to the CD3 receptor complex on T cells. Moreover, the invention providesa nucleic acid sequence encoding the bispecific binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention providesa process for the production of the bispecific binding molecule of the invention, a medical use of said bispecific binding molecule and a kit comprising said bispecific binding molecule.
IPC 8 full level
C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/46 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 37/02 (2017.12); C07K 16/2809 (2013.01); C07K 16/3007 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)
Citation (search report)
See references of WO 2013041687A1
Citation (examination)
N. HOLE, P.L. STERN: "A 72 kD trophoblast glycoprotein defined by a monoclonal antibody", BR. J. CANCER, vol. 57, 1988, pages 239 - 246, XP002653671
Citation (third parties)
Third party :
- WO 03002143 A1 20030109 - ACTIVE BIOTECH AB [SE], et al
- US 2006286634 A1 20061221 - KINGSMAN SUSAN M [GB], et al
- WO 2007106744 A2 20070920 - WYETH CORP [US], et al
- WO 0238612 A2 20020516 - OXFORD BIOMEDICA LTD [GB], et al
- FORSBERG G. ET AL.: "IDENTIFICATION OF FRAMEWORK RESIDUES IN A SECRETED RECOMBINANT ANTIBODY FRAGMENT THAT CONTROL PRODUCTION LEVEL AND LOCALIZATION IN ESCHERICHIA COLI", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 19, 1997, pages 12430 - 12436, XP002389356
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2013041687 A1 20130328; AU 2012311492 A1 20140306; CA 2846432 A1 20130328; EP 2758438 A1 20140730; JP 2014533929 A 20141218; MX 2014003313 A 20140709
DOCDB simple family (application)
EP 2012068673 W 20120921; AU 2012311492 A 20120921; CA 2846432 A 20120921; EP 12778970 A 20120921; JP 2014531248 A 20120921; MX 2014003313 A 20120921