EP 2776417 B1 20181031 - 5-(PYRIDIN-2-YL-AMINO)-PYRAZINE-2-CARBONITRILE COMPOUNDS AND THEIR THERAPEUTIC USE
Title (en)
5-(PYRIDIN-2-YL-AMINO)-PYRAZINE-2-CARBONITRILE COMPOUNDS AND THEIR THERAPEUTIC USE
Title (de)
5-(PYRIDIN-2-YL-AMINO)-PYRAZIN-2-CARBONITRILVERBINDUNGEN UND THERAPEUTISCHE VERWENDUNG DAVON
Title (fr)
COMPOSÉS DE TYPE 5-(PYRIDIN-2-YL-AMINO)-PYRAZINE-2-CARBONITRILE ET LEUR UTILISATION THÉRAPEUTIQUE
Publication
Application
Priority
- US 201161557457 P 20111109
- GB 2012052786 W 20121109
Abstract (en)
[origin: WO2013068755A1] The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain pyridyl-amino-pyrazine carbonitrile compounds that, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or II inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or thymidylate synthase (TS) inhibitor; (d) a microtubule targeted agent; and (e) ionising radiation.
IPC 8 full level
C07D 401/12 (2006.01); A61K 31/497 (2006.01); A61P 35/00 (2006.01); C07D 401/14 (2006.01)
CPC (source: CN EP RU US)
A61K 9/0053 (2013.01 - US); A61K 31/497 (2013.01 - EP RU US); A61K 45/06 (2013.01 - US); A61N 5/10 (2013.01 - US); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 401/12 (2013.01 - CN EP RU US); C07D 401/14 (2013.01 - CN EP RU US); A61N 2005/1098 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2013068755 A1 20130516; AU 2012335409 A1 20140417; AU 2012335409 B2 20170713; BR 112014010938 A2 20170516; CA 2849566 A1 20130516; CA 2849566 C 20210209; CN 104105696 A 20141015; CN 104105696 B 20171114; EP 2776417 A1 20140917; EP 2776417 B1 20181031; ES 2709003 T3 20190412; JP 2014532751 A 20141208; JP 6073910 B2 20170201; RU 2014121334 A 20151220; RU 2641693 C2 20180122; US 2014315925 A1 20141023; US 2015225372 A1 20150813; US 2016304493 A1 20161020; US 9040540 B2 20150526; US 9403797 B2 20160802; US 9765059 B2 20170919
DOCDB simple family (application)
GB 2012052786 W 20121109; AU 2012335409 A 20121109; BR 112014010938 A 20121109; CA 2849566 A 20121109; CN 201280055367 A 20121109; EP 12784666 A 20121109; ES 12784666 T 20121109; JP 2014540552 A 20121109; RU 2014121334 A 20121109; US 201214356626 A 20121109; US 201514693307 A 20150422; US 201615191967 A 20160624