EP 2780029 A1 20140924 - ORAL LEPTIN FORMULATIONS AND USES THEREOF
Title (en)
ORAL LEPTIN FORMULATIONS AND USES THEREOF
Title (de)
ORALE LEPTINFORMULIERUNGEN UND IHRE VERWENDUNG
Title (fr)
FORMULATIONS ORALES DE LEPTINE ET LEURS UTILISATIONS
Publication
Application
Priority
CA 2011050720 W 20111118
Abstract (en)
[origin: WO2013071396A1] An oral combination therapy or oral composition that protects orally administered exogenous leptin from the environment of the gastrointestinal tract, allowing delivery of the exogenous leptin to the bloodstream. The oral combination therapy includes (a) leptin or a leptin functional derivative; (b) a stomach acid-neutralizing agent such as a buffer; and (c) a pancreatic protease inhibitor that protects the exogenous leptin from degradation by pancreatic enzymes; and (d) a bile acid or a bile acid analog that facilitates absorption of the exogenous leptin. The oral combination therapy or oral composition may also include at least one agent that stimulates endogenous leptin secretion; as well as at least one agent capable of promoting, enhancing or improving adherence to treatment such as a sweetener or a satiety triggering agent. The oral combination therapy or oral composition can be a single composition in liquid or solid form, or can be administered simultaneously or sequentially so that the components mix in the stomach cavity of the patient. Methods and uses relating to the above oral combination therapy or oral composition to treat or prevent diseases of conditions that are associated with or can be ameliorated by leptin (e.g., obesity, weight gain, diabetes) are also included.
IPC 8 full level
A61K 38/22 (2006.01); A23L 33/17 (2016.01); A61K 9/00 (2006.01); A61K 31/203 (2006.01); A61K 31/56 (2006.01); A61K 31/575 (2006.01); A61K 38/28 (2006.01); A61K 38/57 (2006.01); A61K 45/06 (2006.01); A61P 3/00 (2006.01); C07K 14/575 (2006.01); C07K 14/81 (2006.01)
CPC (source: EP)
A23L 33/10 (2016.07); A61K 9/0095 (2013.01); A61K 31/198 (2013.01); A61K 31/203 (2013.01); A61K 31/575 (2013.01); A61K 38/2207 (2013.01); A61K 38/2235 (2013.01); A61K 38/2264 (2013.01); A61K 38/28 (2013.01); A61K 38/57 (2013.01); A61K 45/06 (2013.01); A61P 3/00 (2017.12); A23V 2002/00 (2013.01); C07K 14/5759 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2013071396 A1 20130523; CA 2855545 A1 20130523; EP 2780029 A1 20140924; EP 2780029 A4 20150624
DOCDB simple family (application)
CA 2011050720 W 20111118; CA 2855545 A 20111118; EP 11875859 A 20111118