EP 2785372 B1 20190619 - INFLUENZA VIRUS VACCINES AND USES THEREOF
Title (en)
INFLUENZA VIRUS VACCINES AND USES THEREOF
Title (de)
INFLUENZAVIRENIMPFSTOFFE UND IHRE VERWENDUNGEN
Title (fr)
VACCINS CONTRE LA GRIPPE ET UTILISATIONS ASSOCIÉES
Publication
Application
Priority
- EP 11191003 A 20111128
- US 201161564086 P 20111128
- EP 11191009 A 20111128
- US 201161564198 P 20111128
- EP 12166268 A 20120501
- US 201261720281 P 20121030
- EP 2012073706 W 20121127
- EP 12791759 A 20121127
Abstract (en)
[origin: WO2013079473A1] The present invention provides influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1 N-terminal stem segment, covalently linked by a linking sequence of 0-50 amino acid residues to an HA1 C-terminal stem segment, and (b) an influenza hemagglutinin HA2 domain, wherein on or more amino acids in the HA2 domain have been mutated. Also provided are nucleic acids encoding the polypeptides, compositions comprising the polypeptides and/or nucleic acid molecules, as well as methods of their use, in particular in the detection, prevention and/or treatment of influenza.
IPC 8 full level
A61K 39/12 (2006.01); C07K 14/005 (2006.01)
CPC (source: EP US)
A61K 39/12 (2013.01 - EP US); A61K 39/145 (2013.01 - US); A61P 31/14 (2018.01 - EP); A61P 31/16 (2018.01 - EP); C07K 14/005 (2013.01 - EP US); C07K 16/1018 (2013.01 - US); C12N 7/00 (2013.01 - US); A61K 39/00 (2013.01 - EP US); A61K 2039/5258 (2013.01 - US); A61K 2039/55522 (2013.01 - EP US); A61K 2039/575 (2013.01 - US); C07K 2317/33 (2013.01 - US); C07K 2317/76 (2013.01 - US); C07K 2319/21 (2013.01 - EP US); C07K 2319/35 (2013.01 - EP US); C07K 2319/40 (2013.01 - US); C07K 2319/50 (2013.01 - EP US); C07K 2319/73 (2013.01 - EP US); C12N 2760/16122 (2013.01 - EP US); C12N 2760/16134 (2013.01 - EP US); C12N 2760/16151 (2013.01 - US); C12N 2760/16171 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2013079473 A1 20130606; AR 089005 A1 20140723; AU 2012343981 A1 20140710; AU 2012343981 B2 20170907; BR 112014012681 A2 20170613; BR 112014012681 A8 20170620; CA 2857087 A1 20130606; CA 2857087 C 20210525; CN 104066446 A 20140924; CN 104066446 B 20171003; EA 033386 B1 20191031; EA 201491051 A1 20150430; EP 2785372 A1 20141008; EP 2785372 B1 20190619; EP 3566714 A1 20191113; HK 1199211 A1 20150626; IL 232780 A0 20140731; IL 232780 A 20170928; IN 4742CHN2014 A 20150918; JP 2015502353 A 20150122; JP 6294828 B2 20180314; KR 101983989 B1 20190531; KR 20140099515 A 20140812; MX 2014006396 A 20140722; MX 357009 B 20180622; MY 170927 A 20190919; NZ 625973 A 20160930; PH 12014501118 A1 20140804; PH 12014501118 B1 20140804; SG 11201402633U A 20140926; TW 201329101 A 20130716; TW I618715 B 20180321; US 2014357845 A1 20141204; US 2016355553 A1 20161208; US 2016362455 A1 20161215; US 9452211 B2 20160927; US 9969778 B2 20180515; ZA 201404797 B 20220330
DOCDB simple family (application)
EP 2012073706 W 20121127; AR P120104458 A 20121128; AU 2012343981 A 20121127; BR 112014012681 A 20121127; CA 2857087 A 20121127; CN 201280067834 A 20121127; EA 201491051 A 20121127; EP 12791759 A 20121127; EP 19175392 A 20121127; HK 14112786 A 20141222; IL 23278014 A 20140525; IN 4742CHN2014 A 20140624; JP 2014542883 A 20121127; KR 20147017628 A 20121127; MX 2014006396 A 20121127; MY PI2014701354 A 20121127; NZ 62597312 A 20121127; PH 12014501118 A 20140519; SG 11201402633U A 20121127; TW 101144619 A 20121128; US 201214361281 A 20121127; US 201615243738 A 20160822; US 201615253535 A 20160831; ZA 201404797 A 20140627