EP 2787007 A2 20141008 - Subcutaneously administered ANTI-IL-6 receptor antibody

Title (en)

Subcutaneously administered ANTI-IL-6 receptor antibody

Title (de)

Subkutan verabreichter ANTI-IL-6-Rezeptorantikörper

Title (fr)

Anticorps du récepteur ANTI-IL-6 administré par voie sous-cutanée

Publication

EP 2787007 A2 20141008 (EN)

Application

EP 13198771 A 20111107

Previously filed application

PCT/US2011/059519 20111107 WO

Priority

US 41101510 P 20101108
US 201161542615 P 20111003
EP 11782516 A 20111107

Abstract (en)

The present application discloses methods for treating an IL-6-mediated disorder such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic JIA (sJIA), polyarticular course JIA (pcJIA), systemic sclerosis, or giant cell arteritis (GCA), with subcutaneously administered antibody that binds interleukin-6 receptor (anti-IL-6R antibody). In particular, it relates to identification of a fixed dose of anti-IL-6R antibody, e.g. tocilizumab, which is safe and effective for subcutaneous administration in patients with IL-6-mediated disorders. In addition, formulations and devices useful for subcutaneous administration of an anti-IL-6R antibody are disclosed.

IPC 8 full level

C07K 16/28 (2006.01); A61K 38/47 (2006.01); A61K 39/395 (2006.01)

CPC (source: EP KR US)

A61K 9/0019 (2013.01 - EP US); A61K 31/573 (2013.01 - EP US); A61K 38/47 (2013.01 - EP US); A61K 39/39533 (2013.01 - US); A61K 39/3955 (2013.01 - EP US); A61P 9/00 (2018.01 - EP); A61P 9/14 (2018.01 - EP); A61P 17/00 (2018.01 - EP); A61P 17/06 (2018.01 - EP); A61P 19/02 (2018.01 - EP KR); A61P 21/00 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 37/06 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 16/2866 (2013.01 - EP KR US); C12Y 302/01035 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP KR US); A61K 2039/54 (2013.01 - EP KR US); A61K 2039/545 (2013.01 - EP KR US); A61K 2300/00 (2013.01 - EP US); A61P 19/02 (2018.01 - US); A61P 29/00 (2018.01 - US); A61P 37/06 (2018.01 - US); C07K 2317/24 (2013.01 - EP KR US); C07K 2317/76 (2013.01 - EP KR US); C07K 2317/94 (2013.01 - EP KR US)

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Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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