EP 2790731 A2 20141022 - FGFR-BINDER-ACTIVE AGENT CONJUGATES
Title (en)
FGFR-BINDER-ACTIVE AGENT CONJUGATES
Title (de)
FGFR-BINDER-WIRKSTOFF KONJUGATE UND IHRE VERWENDUNG
Title (fr)
CONJUGUÉES DE LIEUR FGFR ET DE PRINCIPE ACTIF
Publication
Application
Priority
- EP 11193617 A 20111214
- EP 12189467 A 20121022
- EP 2012075277 W 20121212
- EP 12808324 A 20121212
Abstract (en)
[origin: WO2013087716A2] The present application relates to new antibody drug conjugates (ADCs) of N,N dialkylauristatins directed against the target FGFR2, drug metabolites of said ADCs, a method for producing said ADCs, the use of said ADCs for the treatment and/or prevention of illnesses as well as the use of said ADCs for producing pharmaceuticals for the treatment and/or prevention of illnesses, particularly of hyperproliferative and/or angiogenic diseases such as carcinosis. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures.
IPC 8 full level
A61K 47/48 (2006.01)
CPC (source: EP KR US)
A61K 38/05 (2013.01 - EP US); A61K 39/395 (2013.01 - KR); A61K 47/30 (2013.01 - KR); A61K 47/50 (2017.07 - KR); A61K 47/6849 (2017.07 - EP US); A61P 35/00 (2017.12 - EP); C07K 11/00 (2013.01 - KR)
Citation (search report)
See references of WO 2013087716A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2013087716 A2 20130620; WO 2013087716 A3 20130822; AR 089252 A1 20140806; AU 2012351685 A1 20140703; BR 112014014763 A2 20170613; BR 112014014763 A8 20170704; CA 2859255 A1 20130620; CN 104254342 A 20141231; EP 2790731 A2 20141022; HK 1200714 A1 20150814; IL 233050 A0 20140731; JP 2015505850 A 20150226; KR 20140114826 A 20140929; MX 2014007121 A 20140904; NZ 625745 A 20160729; RU 2014128467 A 20160210; SG 11201403085P A 20141030; US 2015023989 A1 20150122; ZA 201405003 B 20160127
DOCDB simple family (application)
EP 2012075277 W 20121212; AR P120104728 A 20121214; AU 2012351685 A 20121212; BR 112014014763 A 20121212; CA 2859255 A 20121212; CN 201280069771 A 20121212; EP 12808324 A 20121212; HK 15101201 A 20150204; IL 23305014 A 20140610; JP 2014546496 A 20121212; KR 20147019085 A 20121212; MX 2014007121 A 20121212; NZ 62574512 A 20121212; RU 2014128467 A 20121212; SG 11201403085P A 20121212; US 201214364203 A 20121212; ZA 201405003 A 20140709