EP 2794007 A4 20151118 - COMPOSITIONS AND METHODS FOR TREATMENT OF THROMBOSIS AND PROLONGING SURVIVAL OF STORED PLATELETS
Title (en)
COMPOSITIONS AND METHODS FOR TREATMENT OF THROMBOSIS AND PROLONGING SURVIVAL OF STORED PLATELETS
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON THROMBOSEN UND ZUR VERLÄNGERUNG DER LEBENSDAUER GELAGERTER THROMBOZYTEN
Title (fr)
COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE THROMBOSE ET LA PROLONGATION DE LA SURVIE DE PLAQUETTES STOCKÉES
Publication
Application
Priority
- US 201161580110 P 20111223
- US 2012071530 W 20121222
Abstract (en)
[origin: WO2013096932A1] Provided herein are methods and compositions, including pharmaceutical compositions, for treating vaso- occlusion related to sickle cell anemia, thrombosis, vascular inflammation, and thrombocytopenia. The methods and compositions of the present invention are also useful for extending the useful storage shelf life of platelets, through addition of a GPIba-binding cyclic peptide fusion protein (GCPF).
IPC 8 full level
A61P 7/02 (2006.01); A61K 38/12 (2006.01)
CPC (source: EP)
A61K 38/1709 (2013.01); A61K 47/60 (2017.07); A61P 7/02 (2017.12); A61K 38/00 (2013.01); C07K 2319/30 (2013.01)
Citation (search report)
- [XP] WO 2011162831 A2 20111229 - VASCULOGICS INC [US], et al
- [Y] BENARD S A ET AL: "Identification of peptide antagonists to glycoprotein Ib[alpha] that selectively inhibit von Willebrand factor dependent platelet aggregation", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 47, no. 16, 22 April 2008 (2008-04-22), pages 4674 - 4682, XP002605297, ISSN: 0006-2960, [retrieved on 20080326], DOI: 10.1021/BI702428Q
- [Y] MCEWAN P A ET AL: "Glycoprotein Ib[alpha] inhibitor complex structure reveals a combined steric and allosteric mechanism of von Willebrand factor antagonism", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 114, no. 23, 26 November 2009 (2009-11-26), pages 4883 - 4885, XP002605298, ISSN: 0006-4971, [retrieved on 20090902], DOI: 10.1182/BLOOD-2009-05-224170
- [Y] KAREN VANHOORELBEKE ET AL: "Inhibition of Platelet Glycoprotein Ib and Its Antithrombotic Potential", CURRENT PHARMACEUTICAL DESIGN, vol. 13, no. 26, 1 September 2007 (2007-09-01), pages 2684 - 2697, XP055091439, ISSN: 1381-6128, DOI: 10.2174/138161207781662867
- [Y] VIKTORIA RUMJANTSEVA ET AL: "Dual roles for hepatic lectin receptors in the clearance of chilled platelets", NATURE MEDICINE, vol. 15, no. 11, 27 November 2009 (2009-11-27), pages 1273 - 1280, XP055065743, ISSN: 1078-8956, DOI: 10.1038/nm.2030
- See references of WO 2013096932A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2013096932 A1 20130627; CA 2871057 A1 20130627; EP 2794007 A1 20141029; EP 2794007 A4 20151118
DOCDB simple family (application)
US 2012071530 W 20121222; CA 2871057 A 20121222; EP 12859158 A 20121222