Global Patent Index - EP 2799451 A1

EP 2799451 A1 20141105 - Generation and profiling of fully human HuCAL GOLD®-derived therapeutic antibodies specific for human CD38

Title (en)

Generation and profiling of fully human HuCAL GOLD®-derived therapeutic antibodies specific for human CD38

Title (de)

Gewinnung und Profiling von vollständig humanen, von HUCAL-Gold(RTM)-abgeleiteten therapeutischen, für humanes CD38 spezifischen Antikörpern

Title (fr)

Production et profilage d'anticorps thérapeutiques dérivés de la technologie Hucal gold(rtm) entièrement humains spécifiques à la protéine humaine cd38

Publication

EP 2799451 A1 20141105 (EN)

Application

EP 14164595 A 20060524

Priority

  • US 68377205 P 20050524
  • US 70600405 P 20050808
  • EP 06761936 A 20060524

Abstract (en)

The invention pertains to a human or humanized anti-CD38 antibody or functional fragment thereof for use in a method of treating a tumor disease, in particular a haematological disease, by inducing specific killing of tumor cells that express CD38 by CD38 cross-linking. The antibody for use according to the invention include an antibody characterized by a variable heavy chain having the amino acid sequence of SEQ ID NO:6 and a variable light chain having the amino acid sequence of SEQ ID NO:14, an antibody characterized a variable heavy chain having the amino acid sequence of SEQ ID NO:5 and a variable light chain having the amino acid sequence of SEQ ID NO:13 as well as variants thereof.

IPC 8 full level

C07K 16/28 (2006.01); A61P 35/00 (2006.01)

CPC (source: EP US)

A61P 35/00 (2017.12 - EP); C07K 16/2896 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2317/21 (2013.01 - EP US); C07K 2317/34 (2013.01 - EP US); C07K 2317/55 (2013.01 - EP US)

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Citation (search report)

  • [Y] WO 9616990 A1 19960606 - WELLCOME FOUND [GB], et al
  • [Y] WO 2005042019 A1 20050512 - UNIV ROCHESTER [US], et al
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Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2006125640 A2 20061130; WO 2006125640 A3 20070412; AR 053489 A1 20070509; EP 1888647 A2 20080220; EP 2799451 A1 20141105; TW 200745162 A 20071216; US 2009123950 A1 20090514

DOCDB simple family (application)

EP 2006004991 W 20060524; AR P060102164 A 20060524; EP 06761936 A 20060524; EP 14164595 A 20060524; TW 95118554 A 20060524; US 92083006 A 20060524