Title (en)

Identification of biologically and clinically essential genes and gene pairs, and methods employing the identified genes and gene pairs

Title (de)

Identifizierung von biologisch und klinisch essentiellen Genen und Genpaaren sowie Verfahren zur Anwendung der identifizierten Gene und Genpaare

Title (fr)

Identification de gènes et de paires de gènes biologiquement et cliniquement essentiels et procédés utilisant les gènes et paires de gènes identifiés

Publication

EP 2808815 A3 20150325 (EN)

Application

EP 14174952 A 20100310

Priority

• US 15894809 P 20090310
• EP 10751103 A 20100310

Abstract (en)

[origin: WO2010104473A1] A method is proposed identification of pairs of genes for which the respective gene expression values in a subject are statistically significant in relation to a medical condition, for example cancer, or more particularly breast cancer. Many pairs of genes are generated, and for each pair of genes clinical data is used to fit a statistical model to obtain the statistical significance of the ratio of the corresponding expression values. The clinical data characterizes for each of the patients the level of expressions of the genes and times until a clinical endpoint of interest.

IPC 8 full level

G16B 20/20 (2019.01); G16B 25/10 (2019.01); G16B 40/30 (2019.01)

CPC (source: EP US)

C12Q 1/6837 (2013.01 - EP US); C12Q 1/6886 (2013.01 - EP US); G16B 20/20 (2019.01 - EP US); G16B 25/10 (2019.01 - EP US); G16B 40/00 (2019.01 - EP US); G16B 40/30 (2019.01 - EP US); C12Q 2600/118 (2013.01 - EP US); G16B 20/00 (2019.01 - EP US); G16B 25/00 (2019.01 - EP US)

Citation (search report)

• [X] C. FLOTHO ET AL: "A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia", BLOOD, vol. 110, no. 4, 15 August 2007 (2007-08-15), pages 1271 - 1277, XP055143497, ISSN: 0006-4971, DOI: 10.1182/blood-2007-01-068478
• [X] BYUNGWOO RYU ET AL: "Comprehensive Expression Profiling of Tumor Cell Lines Identifies Molecular Signatures of Melanoma Progression", PLOS ONE, vol. 2, no. 7, 1 July 2007 (2007-07-01), pages e594, XP055143559, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0000594
• [X] BROUARD S ET AL: "Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 104, no. 39, 25 September 2007 (2007-09-25), pages 15448 - 15453, XP002594926, ISSN: 0027-8424, [retrieved on 20070914], DOI: 10.1073/PNAS.0705834104
• [A] ROSS JEFFREY S ET AL: "Commercialized multigene predictors of clinical outcome for breast cancer", THE ONCOLOGIST, ALPHAMED PRESS, US, vol. 13, no. 5, 1 May 2008 (2008-05-01), pages 477 - 493, XP002541429, ISSN: 1083-7159, DOI: 10.1634/THEONCOLOGIST.2007-0248
• [A] ROSELL RAFAEL ET AL: "BRCA1: a novel prognostic factor in resected non-small-cell lung cancer", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 2, no. 11, 7 November 2007 (2007-11-07), pages e1129 - 1, XP002490290, ISSN: 1932-6203, DOI: 10.1371/JOURNAL.PONE.0001129

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DOCDB simple family (publication)

WO 2010104473 A1 20100916; EP 2406729 A1 20120118; EP 2406729 A4 20140101; EP 2406729 B1 20170705; EP 2406730 A1 20120118; EP 2406730 A4 20140101; EP 2808815 A2 20141203; EP 2808815 A3 20150325; SG 10201403038S A 20141030; SG 10201403064Q A 20141030; SG 173635 A1 20110929; SG 174333 A1 20111028; US 2012004135 A1 20120105; US 2012117018 A1 20120510; US 2016040221 A1 20160211; WO 2010104474 A1 20100916

DOCDB simple family (application)

SG 2010000079 W 20100310; EP 10751102 A 20100310; EP 10751103 A 20100310; EP 14174952 A 20100310; SG 10201403038S A 20100310; SG 10201403064Q A 20100310; SG 2010000080 W 20100310; SG 2011057700 A 20100310; SG 2011065406 A 20100310; US 201013255490 A 20100310; US 201013255898 A 20100310; US 201414301296 A 20140610