EP 2812690 A2 20141217 - DIAGNOSING MULTIPLE SCLEROSIS
Title (en)
DIAGNOSING MULTIPLE SCLEROSIS
Title (de)
DIAGNOSE MULTIPLER SKLEROSE
Title (fr)
DIAGNOSTIC DE LA SCLÉROSE EN PLAQUES
Publication
Application
Priority
- GB 201202092 A 20120207
- GB 2013050285 W 20130207
Abstract (en)
[origin: WO2013117930A2] There is provided an in vitro method for diagnosing Multiple Sclerosis (MS) in a human test subject, comprising (i) determining the concentrations of two or more metabolites in a sample from said subject, wherein said two or more metabolites are selected from: blood metabolites, wherein said blood metabolites comprise: alanine, ascorbic acid, choline, fatty acid, glucose, lactate, N-acetyl aspartate, N-acetyl glycoprotein, n-butyrate, oxyglutaric acid, phosphocholine, taurinebetaine, tyrosine, L-glutamine, N-acetyl species, and beta-hydroxybutyrate; and/or urine metabolites, wherein said urine metabolites comprise: citrate, creatinine, inositol, lactate and trimethylamine N-oxide (TMAO); (ii) comparing the concentrations of said two or more metabolites in the sample with the concentrations of the same metabolites in at least one reference standard; and (iii) identifying a concentration difference for each of said two or more metabolites in the sample relative to the reference standard; wherein said concentration differences correlate with the presence of MS.
IPC 8 full level
G01N 33/50 (2006.01)
CPC (source: EP US)
G01N 33/492 (2013.01 - EP US); G01N 33/493 (2013.01 - EP US); G01N 33/50 (2013.01 - US); G01N 33/564 (2013.01 - EP US); G01N 2570/00 (2013.01 - EP US); G01N 2800/285 (2013.01 - EP US)
Citation (search report)
See references of WO 2013117930A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2013117930 A2 20130815; WO 2013117930 A3 20131114; AU 2013217415 A1 20140925; AU 2013217415 B2 20180809; CA 2864026 A1 20130815; CA 2864026 C 20230822; EP 2812690 A2 20141217; EP 2812690 B1 20170726; ES 2642186 T3 20171115; GB 201202092 D0 20120321; US 2015338389 A1 20151126; US 2018372716 A1 20181227
DOCDB simple family (application)
GB 2013050285 W 20130207; AU 2013217415 A 20130207; CA 2864026 A 20130207; EP 13704627 A 20130207; ES 13704627 T 20130207; GB 201202092 A 20120207; US 201314377454 A 20130207; US 201815963271 A 20180426