Global Patent Index - EP 2820131 A2

EP 2820131 A2 20150107 - USE OF MICRO-RNAS OR GENES AS MARKERS FOR THE IDENTIFICATION, DIAGNOSIS AND THERAPY OF INDIVIDUAL FORMS OF NON-ISCHEMIC CARDIOMYOPATHIES OR STORAGE DISEASES OF THE HEART

Title (en)

USE OF MICRO-RNAS OR GENES AS MARKERS FOR THE IDENTIFICATION, DIAGNOSIS AND THERAPY OF INDIVIDUAL FORMS OF NON-ISCHEMIC CARDIOMYOPATHIES OR STORAGE DISEASES OF THE HEART

Title (de)

VERWENDUNG VON MICRORNAS ODER GENEN ALS MARKER ZUR IDENTIFIZIERUNG, DIAGNOSE UND THERAPIE EINZELNER FORMEN NICHT-ISCHÄMISCHER KARDIOMYOPATHIEN ODER SPEICHERERKRANKUNGEN DES HERZENS

Title (fr)

UTILISATION DE MICRO-ARN OU DE GÈNES COMME MARQUEURS POUR L'IDENTIFICATION, LE DIAGNOSTIC ET LE TRAITEMENT DE FORMES INDIVIDUELLES DE CARDIOMYOPATHIES NON ISCHÉMIQUES OU DE MALADIES DE SURCHARGE DU C UR

Publication

EP 2820131 A2 20150107 (DE)

Application

EP 13712154 A 20130226

Priority

  • DE 102012101557 A 20120227
  • EP 2013053800 W 20130226

Abstract (en)

[origin: WO2013127782A2] The invention relates to the use of certain microRNAs and/or genes, both individually and as a combination of several, in the form of profiles as markers for identifying individual forms of non-ischemic cardiomyopathies or storage diseases of the heart, and to their use in diagnostic systems for identifying individual forms of non-ischemic cardiomyopathies or storage diseases of the heart, which includes at least some of these microRNAs and/or genes. The invention furthermore relates to a method for identifying and differentiating between individual forms of non-ischemic cardiomyopathies or storage diseases of the heart using at least individual ones of these microRNAs and/or genes. The invention further relates to a medicament which contains at least one nucleic acid which includes a sequence which is identical or complementary to the sequence of one of these microRNAs.

IPC 8 full level

C12N 15/113 (2010.01); A61K 31/7088 (2006.01); A61P 9/00 (2006.01); C12Q 1/68 (2006.01)

CPC (source: EP)

A61P 9/00 (2017.12); C12N 15/111 (2013.01); C12N 2310/141 (2013.01); C12N 2320/10 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01)

Citation (search report)

See references of WO 2013127782A2

Citation (examination)

  • WO 2009033185 A1 20090312 - UNIV MASSACHUSETTS [US], et al
  • CORSTEN M F ET AL: "Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease", CIRCULATION: CARDIOVASCULAR GENETICS, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 3, no. 6, 4 October 2010 (2010-10-04), pages 499 - 506, XP002742531, ISSN: 1942-325X, [retrieved on 20101004], DOI: 10.1161/CIRCGENETICS.110.957415
  • ANONYMOUS: "Cellular MicroRNAs as Molecular Determinants of Coxsackievirus Tissue Tropism and Pathogenesis", May 2011 (2011-05-01), XP055237252, Retrieved from the Internet <URL:http://www.im.cas.cn/xshd/201105/t20110523_3139018.html> [retrieved on 20151217]
  • HONG-FEI XU ET AL: "MicroRNA- 1 represses Cx43 expression in viral myocarditis", MOLECULAR AND CELLULAR BIOCHEMISTRY, KLUWER ACADEMIC PUBLISHERS, BO, vol. 362, no. 1 - 2, 2 November 2011 (2011-11-02), pages 141 - 148, XP035010592, ISSN: 1573-4919, DOI: 10.1007/S11010-011-1136-3
  • S. K. GUPTA ET AL: "Circulating MicroRNAs as Biomarkers and Potential Paracrine Mediators of Cardiovascular Disease", CIRCULATION: CARDIOVASCULAR GENETICS, vol. 3, no. 5, October 2010 (2010-10-01), US, pages 484 - 488, XP055237788, ISSN: 1942-325X, DOI: 10.1161/CIRCGENETICS.110.958363
  • KÜHL U ET AL: "miRNA as activity markers in Parvo B19 associated heart disease ; miRNA als ein Aktivitätsmarker der Parvovirus-B19-assoziierten Herzmuskelerkrankung", HERZ KARDIOVASKULÄRE ERKRANKUNGEN, URBAN & VOGEL, MU, vol. 37, no. 6, 8 August 2012 (2012-08-08), pages 637 - 643, XP035115557, ISSN: 1615-6692, DOI: 10.1007/S00059-012-3656-3
  • IKEDA SADAKATSU ET AL: "Altered microRNA expression in human heart disease", PHYSIOLOGICAL GENOMICS, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 31, no. 3, 21 August 2007 (2007-08-21), pages 367 - 373, XP009098819, ISSN: 1094-8341

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

DE 102012101557 A1 20130829; DE 112013001154 A5 20141211; EP 2820131 A2 20150107; WO 2013127782 A2 20130906; WO 2013127782 A3 20131121

DOCDB simple family (application)

DE 102012101557 A 20120227; DE 112013001154 T 20130226; EP 13712154 A 20130226; EP 2013053800 W 20130226