Global Patent Index - EP 2822571 A4

EP 2822571 A4 20160309 - MODULATORS OF ACYL-COA LYSOCARDIOLIPIN ACYLTRANSFERASE 1 ( ALCAT1) AND USES THEREOF

Title (en)

MODULATORS OF ACYL-COA LYSOCARDIOLIPIN ACYLTRANSFERASE 1 ( ALCAT1) AND USES THEREOF

Title (de)

MODULATOREN VON ACYL-COA-LYSOCARDIOLIPIN-ACYLTRANSFERASE-1 (ALCAT1) UND VERWENDUNGEN DAVON

Title (fr)

MODULATEURS DE L'ACYL-COA LYSOCARDIOLIPINE ACYLTRANSFÉRASE 1 (ALCAT1) ET LEURS UTILISATIONS

Publication

EP 2822571 A4 20160309 (EN)

Application

EP 13749685 A 20130215

Priority

  • US 201261599496 P 20120216
  • US 2013026311 W 20130215

Abstract (en)

[origin: WO2013123305A1] Compositions of modulators of acyl-CoA lysocardiolipin acyf transferase 1 (ALCATl ) expression, function or activity are provided. In particular, inhibitors of ALCATl are useful in treating metabolic diseases, cardiac diseases and, in general diseases associated with mitochondrial dysfunction. Assays for identification of novel ALCATl modulators are provided.

IPC 8 full level

A61K 38/17 (2006.01); G01N 33/50 (2006.01)

CPC (source: EP US)

A61K 38/1709 (2013.01 - EP US); A61K 38/46 (2013.01 - EP US); A61K 39/3955 (2013.01 - US); A61P 3/00 (2018.01 - EP); A61P 3/04 (2018.01 - EP); A61P 3/10 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 15/10 (2018.01 - EP); A61P 15/12 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 39/06 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 16/40 (2013.01 - US); C12N 15/1137 (2013.01 - US); C12Q 1/6883 (2013.01 - US); A61K 2039/505 (2013.01 - US); C07K 2317/21 (2013.01 - US); C07K 2317/24 (2013.01 - US); C07K 2317/76 (2013.01 - US); C12N 2310/111 (2013.01 - US); C12Q 2600/136 (2013.01 - US); C12Q 2600/158 (2013.01 - US); C12Y 306/05 (2013.01 - EP US)

Citation (search report)

  • [XYI] J. CAO ET AL: "ALCAT1 is a polyglycerophospholipid acyltransferase potently regulated by adenine nucleotide and thyroid status", AJP: ENDOCRINOLOGY AND METABOLISM, vol. 296, no. 4, 23 December 2008 (2008-12-23), pages E647 - E653, XP055080905, ISSN: 0193-1849, DOI: 10.1152/ajpendo.90761.2008
  • [Y] JIA LI ET AL: "Cardiolipin Remodeling by ALCAT1 Links Oxidative Stress and Mitochondrial Dysfunction to Obesity", CELL METABOLISM, vol. 12, no. 2, 1 August 2010 (2010-08-01), pages 154 - 165, XP055080906, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2010.07.003
  • [Y] YAN YAN ET AL: "Resistance of Alcat1 Null Mice to High Fat Diet Induced Obesity and Impaired Glucose Tolerance", INTERNATIONAL JOURNAL OF BIOLOGY, vol. 3, no. 2, 6 April 2011 (2011-04-06), XP055213381, ISSN: 1916-9671, DOI: 10.5539/ijb.v3n2p11
  • [Y] XU F Y ET AL: "The dynamics of cardiolipin synthesis post-mitochondrial fusion", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - BIOMEMBRANES, ELSEVIER, AMSTERDAM, NL, vol. 1798, no. 8, 1 August 2010 (2010-08-01), pages 1577 - 1585, XP027085589, ISSN: 0005-2736, [retrieved on 20100613]
  • [Y] MING ZHENG ET AL: "Role of mitofusin 2 in cardiovascular oxidative injury", JOURNAL OF MOLECULAR MEDICINE, SPRINGER, BERLIN, DE, vol. 88, no. 10, 8 September 2010 (2010-09-08), pages 987 - 991, XP019823120, ISSN: 1432-1440

Citation (examination)

  • WO 9855618 A1 19981210 - UNIV LELAND STANFORD JUNIOR [US]
  • GUO ET AL: "Overexpression of Mitofusin 2 inhibited oxidized low-density lipoprotein induced vascular smooth muscle cell proliferation and reduced atherosclerotic lesion formation in rabbit", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 363, no. 2, 1 October 2007 (2007-10-01), pages 411 - 417, XP022278099, ISSN: 0006-291X, DOI: 10.1016/J.BBRC.2007.08.191
  • See also references of WO 2013123305A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

WO 2013123305 A1 20130822; CA 2863600 A1 20130822; CN 104302304 A 20150121; EP 2822571 A1 20150114; EP 2822571 A4 20160309; HK 1205952 A1 20151231; JP 2015514966 A 20150521; JP 2017198689 A 20171102; JP 6253596 B2 20171227; JP 6410878 B2 20181024; US 10526418 B2 20200107; US 2015098938 A1 20150409; US 2017320964 A1 20171109; US 9708411 B2 20170718

DOCDB simple family (application)

US 2013026311 W 20130215; CA 2863600 A 20130215; CN 201380009571 A 20130215; EP 13749685 A 20130215; HK 15106695 A 20150714; JP 2014557806 A 20130215; JP 2017113848 A 20170608; US 201314378525 A 20130215; US 201715651758 A 20170717