EP 2826788 A1 20150121 - TARGETING COMPLEMENT FACTOR H FOR TREATMENT OF DISEASES BY THE USE OF CR2-FH MOLECULES

Title (en)

TARGETING COMPLEMENT FACTOR H FOR TREATMENT OF DISEASES BY THE USE OF CR2-FH MOLECULES

Title (de)

TARGETING DES KOMPLEMENT-FAKTORS H ZUR KRANKHEITSBEHANDLUNG MIT CR2-FH MOLEKULEN

Title (fr)

CIBLAGE DE FACTEUR H DU COMPLÉMENT POUR LE TRAITEMENT DE MALADIES UTILISANT DES MOLECULES CR2-FH

Publication

EP 2826788 A1 20150121 (EN)

Application

EP 14170690 A 20070621

Priority

US 81574806 P 20060621
EP 07845250 A 20070621

Abstract (en)

The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age-related macular degeneration, rheumatoid arthritis, and ischemia reperfusion.

IPC 8 full level

C07K 14/435 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP US)

A61P 1/04 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 17/04 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 21/04 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/47 (2013.01 - EP US); C07K 14/705 (2013.01 - EP US); C07K 14/70596 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US)

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Citation (search report)

[AP] WO 2006088950 A2 20060824 - UNIV IOWA RES FOUND [US], et al
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Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

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DOCDB simple family (application)

US 2007014602 W 20070621; AU 2007261315 A 20070621; BR PI0712987 A 20070621; CA 2656063 A 20070621; CN 200780029458 A 20070621; DK 07845250 T 20070621; EP 07845250 A 20070621; EP 14170690 A 20070621; ES 07845250 T 20070621; HK 09108674 A 20090923; HK 15106966 A 20150721; JP 2009516588 A 20070621; PL 07845250 T 20070621; PT 07845250 T 20070621; SI 200731549 T 20070621; US 201314043317 A 20131001; US 78252610 A 20100518; US 82137007 A 20070621