EP 2827907 A1 20150128 - SHORT ANTIMICROBIAL LIPOPEPTIDES
Title (en)
SHORT ANTIMICROBIAL LIPOPEPTIDES
Title (de)
KURZE ANTIMIKROBIELLE LIPOPEPTIDE
Title (fr)
LIPOPEPTIDES ANTIMICROBIENS COURTS
Publication
Application
Priority
- US 201261613212 P 20120320
- US 2013029696 W 20130307
Abstract (en)
[origin: WO2013142088A1] Disclosed are peptides having biological and therapeutic activity. Particularly disclosed are lipidated di- or tri- peptides analogs of KPV or KdPT that exhibit antimicrobial activity. In particular, the peptides of this invention provide enhanced anti-microbial activity over the base tri -peptides, lysine -proline- valine and lysine-d-proline-tyrosine. The disclosed peptides have the general formula of C12-18 lipid- KXZ-NH2i wherein K is lysine; X is proline, d-proline, histidine or arginine; Z is optional and if present Z is valine, threonine, alanine or leucine; and the terminal COOH is NH2 amidated. The C12-18 lipid is preferably the lipid moiety of lauric acid (C12), myristic acid (C14), pentadecanoic acid (C15), palmitic acid (C16), or stearic acid (C18). The invention is further related to methods of using of these peptides to treat various insults, inflammations or bacterial infections affecting the skin and other related mucosal body surfaces such as the oral cavity.
IPC 8 full level
A61K 47/48 (2006.01); A61K 38/34 (2006.01); C07K 5/09 (2006.01)
CPC (source: CN EP KR RU US)
A61K 8/64 (2013.01 - KR); A61K 38/05 (2013.01 - CN EP US); A61K 38/06 (2013.01 - EP US); A61K 38/34 (2013.01 - EP KR US); A61K 47/50 (2017.07 - KR); A61K 47/542 (2017.07 - EP US); A61P 15/02 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 17/10 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 31/02 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 31/10 (2017.12 - EP); A61P 37/08 (2017.12 - EP); C07K 5/06086 (2013.01 - US); C07K 5/0815 (2013.01 - EP KR US); A61K 38/05 (2013.01 - RU); Y02A 50/30 (2017.12 - EP US)
Citation (search report)
See references of WO 2013142088A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2013142088 A1 20130926; AR 090439 A1 20141112; AU 2013235692 A1 20140925; AU 2013235692 B2 20161208; CA 2864179 A1 20130926; CN 104379177 A 20150225; CN 104379177 B 20170704; CN 107080831 A 20170822; DK 2827907 T3 20190611; EP 2827907 A1 20150128; EP 2827907 B1 20190306; ES 2729237 T3 20191031; HK 1204453 A1 20151120; JP 2015512386 A 20150427; JP 6261560 B2 20180117; KR 20140136494 A 20141128; MX 2014011290 A 20141013; MY 163100 A 20170804; PL 2827907 T3 20190830; RU 2014142038 A 20160510; RU 2017127273 A 20190204; RU 2627648 C2 20170809; SG 10201607784V A 20161129; SG 11201405244R A 20141030; TW 201339176 A 20131001; TW I541254 B 20160711; US 2015080291 A1 20150319; US 9278994 B2 20160308; ZA 201405950 B 20170830
DOCDB simple family (application)
US 2013029696 W 20130307; AR P130100903 A 20130320; AU 2013235692 A 20130307; CA 2864179 A 20130307; CN 201380014970 A 20130307; CN 201710009878 A 20130307; DK 13710751 T 20130307; EP 13710751 A 20130307; ES 13710751 T 20130307; HK 15105035 A 20150527; JP 2015501713 A 20130307; KR 20147028361 A 20130307; MX 2014011290 A 20130307; MY PI2014002316 A 20130307; PL 13710751 T 20130307; RU 2014142038 A 20130307; RU 2017127273 A 20130307; SG 10201607784V A 20130307; SG 11201405244R A 20130307; TW 102109748 A 20130319; US 201314385517 A 20130307; ZA 201405950 A 20140813