Global Patent Index - EP 2830620 A4

EP 2830620 A4 20151209 - 4 AMINOPYRIDINE AS A THERAPEUTIC AGENT FOR SPINAL MUSCULAR ATROPHY

Title (en)

4 AMINOPYRIDINE AS A THERAPEUTIC AGENT FOR SPINAL MUSCULAR ATROPHY

Title (de)

4-AMINOPYRIDIN ALS THERAPEUTISCHES MITTEL FÜR SPINALE MUSKELATROPHIE

Title (fr)

4-AMINOPYRIDINE À TITRE D'AGENT THÉRAPEUTIQUE POUR L'AMYOTROPHIE SPINALE (SMA)

Publication

EP 2830620 A4 20151209 (EN)

Application

EP 13769101 A 20130326

Priority

  • US 201261615466 P 20120326
  • US 2013033952 W 20130326

Abstract (en)

[origin: WO2013148740A1] It has been discovered that pharmacological inhibition of K+ channels (using the FDA-approved broad-spectrum K+ channel antagonist 4-AP) positively benefitted smn mutant phenotypes, a result that is consistent with the defective excitability of motor circuits by their interneuron or sensory neuron inputs being a critical consequence of SMN depletion. Based on these observations, certain embodiments of the invention are directed to methods of treatment of SMA by administering therapeutically effective amounts of one or more potassium channel antagonists, including 4-aminopyridine, 4-(dimethylamino)pyridine, 4-(methylamino)pyridine, and 4-(aminomethyl)pyridine. Other embodiments are directed to new pharmaceutical formulations comprising two or more potassium channel antagonists.

IPC 8 full level

A61K 31/4409 (2006.01); A61P 21/00 (2006.01)

CPC (source: CN EP)

A61K 31/4409 (2013.01 - CN EP); A61P 21/00 (2017.12 - EP); A61P 21/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP)

Citation (search report)

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2013148740 A1 20131003; CN 104334174 A 20150204; EP 2830620 A1 20150204; EP 2830620 A4 20151209; JP 2015512409 A 20150427

DOCDB simple family (application)

US 2013033952 W 20130326; CN 201380027537 A 20130326; EP 13769101 A 20130326; JP 2015503478 A 20130326