Global Patent Index - EP 2836217 A4

EP 2836217 A4 20151028 - COMPOSITIONS AND METHODS FOR TREATMENT OF THE SIDE-EFFECTS ASSOCIATED WITH ADMINISTRATION OF CANCER CHEMOTHERAPEUTIC AGENTS

Title (en)

COMPOSITIONS AND METHODS FOR TREATMENT OF THE SIDE-EFFECTS ASSOCIATED WITH ADMINISTRATION OF CANCER CHEMOTHERAPEUTIC AGENTS

Title (de)

ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON NEBENWIRKUNGEN DER VERABREICHUNG VON CHEMOTHERAPEUTISCHEN ANTIKREBSMITTELN

Title (fr)

COMPOSITIONS ET MÉTHODES DESTINÉES AU TRAITEMENT DES EFFETS SECONDAIRES ASSOCIÉS À L'ADMINISTRATION D'AGENTS CHIMIOTHÉRAPEUTIQUES ANTICANCÉREUX

Publication

EP 2836217 A4 20151028 (EN)

Application

EP 13775759 A 20130412

Priority

  • US 201213446328 A 20120413
  • US 2013036326 W 20130412

Abstract (en)

[origin: WO2013155385A1] A composition and method for the treatment of the side-effects associated with the administration of cancer chemotherapeutic agents involves the oral ingestion of a slow release capsule containing adenine and orotate. The administration of a protein pump inhibitor decreases systemic absorption of orotate and the administration of allopurinol decreases the formation of 2,8-dihydroxy adenine from adenine. In an alternative embodiment, cationic liposomes contain purine/pyrimidine precursors. The cationic liposomes bind to the cells lining the mucosa of the intestinal tract and then the contents of the cationic liposome are then taken up in the interior of the cells to prevent the metabolism of the cancer treatment drug 5-FU into a toxic species.

IPC 8 full level

A61K 31/70 (2006.01); A61K 31/415 (2006.01); A61K 31/4439 (2006.01); A61K 31/513 (2006.01); A61K 31/519 (2006.01); A61K 31/52 (2006.01); A61P 35/00 (2006.01)

CPC (source: CN EP)

A61K 31/4439 (2013.01 - CN EP); A61K 31/513 (2013.01 - CN EP); A61K 31/519 (2013.01 - CN EP); A61K 31/52 (2013.01 - CN EP); A61K 31/522 (2013.01 - EP); A61P 1/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP)

C-Set (source: CN EP)

CN

  1. A61K 31/4439 + A61K 2300/00
  2. A61K 31/513 + A61K 2300/00
  3. A61K 31/519 + A61K 2300/00
  4. A61K 31/52 + A61K 2300/00

EP

  1. A61K 31/513 + A61K 2300/00
  2. A61K 31/52 + A61K 2300/00
  3. A61K 31/4439 + A61K 2300/00
  4. A61K 31/522 + A61K 2300/00
  5. A61K 31/519 + A61K 2300/00

Citation (search report)

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2013155385 A1 20131017; CN 104394872 A 20150304; EP 2836217 A1 20150218; EP 2836217 A4 20151028; IN 9546DEN2014 A 20150717; JP 2015518000 A 20150625

DOCDB simple family (application)

US 2013036326 W 20130412; CN 201380031029 A 20130412; EP 13775759 A 20130412; IN 9546DEN2014 A 20141113; JP 2015505934 A 20130412