EP 2839037 A4 20151223 - BIOMARKERS TO IDENTIFY PATIENTS THAT WILL RESPOND TO TREATMENT AND TREATING SUCH PATIENTS
Title (en)
BIOMARKERS TO IDENTIFY PATIENTS THAT WILL RESPOND TO TREATMENT AND TREATING SUCH PATIENTS
Title (de)
BIOMARKER ZUR IDENTIFIZIERUNG VON AUF EINE BEHANDLUNG REAGIERENDE PATIENTEN UND BEHANDLUNG SOLCHER PATIENTEN
Title (fr)
BIOMARQUEURS PERMETTANT D'IDENTIFIER DES PATIENTS QUI RÉAGIRONT À UN TRAITEMENT, ET TRAITEMENT DESDITS PATIENTS
Publication
Application
Priority
- US 201261635336 P 20120419
- US 201261664471 P 20120626
- US 201361778260 P 20130312
- US 2013037355 W 20130419
Abstract (en)
[origin: WO2013158984A1] The invention relates to methods for using biomarkers to identify cancer patients that will or are likely to respond to treatment. Specifically, the invention relates to the use of one or more of three association studies of cancer types, gene mutations, or gene expression levels in order to identify cancer patients that will or are likely to respond to treatment with a histone deacetylase (HDAC) inhibitor, alone or in combination with another cancer treatment. The methods may, optionally, further include treating such patient with an HDAC inhibitor, alone or in combination with another cancer treatment.
IPC 8 full level
C12Q 1/68 (2006.01); A61P 35/00 (2006.01); C12N 15/11 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP US)
A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C12Q 1/6886 (2013.01 - EP US); G01N 33/57415 (2013.01 - EP US); C12Q 2600/106 (2013.01 - EP US); C12Q 2600/156 (2013.01 - EP US); C12Q 2600/158 (2013.01 - EP US); G01N 2333/71 (2013.01 - EP US)
Citation (search report)
- [A] WO 2007067476 A2 20070614 - MERCK & CO INC [US], et al
- [A] WO 2008095050 A1 20080807 - PHARMACYCLICS INC [US], et al
- [A] WO 2011091213 A2 20110728 - ACETYLON PHARMACEUTICALS [US], et al
- [XY] ON BEHALF OF CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA ET AL: "Molecular mechanisms of endocrine resistance and their implication in the therapy of breast cancer", BBA - REVIEWS ON CANCER, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 1795, no. 1, 1 January 2009 (2009-01-01), pages 62 - 81, XP025846547, ISSN: 0304-419X, [retrieved on 20080829], DOI: 10.1016/J.BBCAN.2008.08.003
- [YA] STIMSON L ET AL: "Biomarkers for predicting clinical responses to HDAC inhibitors", CANCER LETTERS, NEW YORK, NY, US, vol. 280, no. 2, 8 August 2009 (2009-08-08), pages 177 - 183, XP026146050, ISSN: 0304-3835, [retrieved on 20090410], DOI: 10.1016/J.CANLET.2009.03.016
- See references of WO 2013158984A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2013158984 A1 20131024; EP 2839037 A1 20150225; EP 2839037 A4 20151223; EP 2839037 B1 20181226; HK 1207403 A1 20160129; JP 2015515279 A 20150528; JP 2019076114 A 20190523; JP 6906554 B2 20210721; US 10648038 B2 20200512; US 2014011767 A1 20140109; US 2017327895 A1 20171116; US 9663825 B2 20170530
DOCDB simple family (application)
US 2013037355 W 20130419; EP 13778809 A 20130419; HK 15108041 A 20150819; JP 2015507216 A 20130419; JP 2019017767 A 20190204; US 201313866367 A 20130419; US 201715497397 A 20170426