EP 2841560 A2 20150304 - PROCESS FOR EX VIVO EXPANSION OF STEM CELLS IN A BIOREACTOR
Title (en)
PROCESS FOR EX VIVO EXPANSION OF STEM CELLS IN A BIOREACTOR
Title (de)
VERFAHREN ZUR EX VIVO VERMEHRUNG VON STAMMZELLEN IN EINEM BIOREAKTOR
Title (fr)
PROCÉDÉ D'EXPANSION EX VIVO DE CELLULES SOUCHES DANS UN BIORÉACTEUR
Publication
Application
Priority
- PT 10622512 A 20120323
- PT 2013000017 W 20130319
Abstract (en)
[origin: WO2013141731A2] The present invention refers to a process of ex vivo expansion of stem cells, in a bioreactor, in particular hematopoietic stem/progenitor cells co-cultured with mesenchymal stem cells immobilized on microcarriers, for transplantation. The process comprises the steps of: a) forming a suspension of mesenchymal stem cells immobilized on microcarriers, b) inoculating in a bioreactor containing an expansion medium, hematopoietic cells co-cultured with mesenchymal stem cells immobilized on microcarriers c) expansion of hematopoietic cells. The process of the invention is capable of being implemented in a Kit.
IPC 8 full level
C12N 5/00 (2006.01); C12N 5/0789 (2010.01)
CPC (source: EP US)
C12N 5/0647 (2013.01 - EP US); C12N 5/0663 (2013.01 - US); C12N 2500/90 (2013.01 - EP US); C12N 2500/92 (2013.01 - US); C12N 2501/115 (2013.01 - EP US); C12N 2501/125 (2013.01 - EP US); C12N 2501/145 (2013.01 - EP US); C12N 2501/26 (2013.01 - EP US); C12N 2502/1171 (2013.01 - US); C12N 2502/1358 (2013.01 - EP US); C12N 2531/00 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2013141731 A2 20130926; WO 2013141731 A3 20131114; WO 2013141731 A8 20141016; AU 2013235884 A1 20141016; CA 2868167 A1 20130926; EP 2841560 A2 20150304; IL 234833 A0 20141231; PT 106225 A 20130923; PT 106225 B 20171103; US 2015050730 A1 20150219
DOCDB simple family (application)
PT 2013000017 W 20130319; AU 2013235884 A 20130319; CA 2868167 A 20130319; EP 13713584 A 20130319; IL 23483314 A 20140923; PT 10622512 A 20120323; US 201314387318 A 20130319