EP 2847333 A4 20151216 - BI-FUNCTIONAL SHORT-HAIRPIN RNA (BI-SHRNA) SPECIFIC FOR SINGLE-NUCLEOTIDE KRAS MUTATIONS
Title (en)
BI-FUNCTIONAL SHORT-HAIRPIN RNA (BI-SHRNA) SPECIFIC FOR SINGLE-NUCLEOTIDE KRAS MUTATIONS
Title (de)
FÜR EINZELNUKLEOTID-KRAS-MUTATIONEN SPEZIFISCHE BIFUNKTIONELLE SHORT-HAIRPIN-RNA (BI-SHRNA)
Title (fr)
ARN BIFONCTIONNEL EN COURTE ÉPINGLE À CHEVEUX (BI-SHARN) SPÉCIFIQUE DES MUTATIONS KRAS PORTANT SUR UN SEUL NUCLÉOTIDE
Publication
Application
Priority
- US 201261644875 P 20120509
- US 2013040407 W 20130509
Abstract (en)
[origin: US2013302407A1] The present invention includes compositions and methods for making and using a bifunctional shRNAs capable of reducing an expression of a K-ras gene, e.g., a mutated K-ras gene, wherein at least one target site sequence of the bifunctional RNA molecule is located within the K-ras gene and wherein the bifunctional RNA molecule is capable of activating a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of K-ras.
IPC 8 full level
C12N 15/113 (2010.01); A61K 9/127 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); B82Y 5/00 (2011.01); C12N 15/85 (2006.01)
CPC (source: EP KR US)
A61K 9/127 (2013.01 - KR US); A61K 31/713 (2013.01 - EP KR US); A61K 45/06 (2013.01 - KR US); A61P 1/04 (2017.12 - EP); A61P 1/18 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C12N 15/1135 (2013.01 - EP KR US); C12N 15/63 (2013.01 - KR); C12N 15/85 (2013.01 - KR); C12Q 1/6897 (2013.01 - US); A61K 2300/00 (2013.01 - KR); C12N 2310/14 (2013.01 - US); C12N 2310/51 (2013.01 - EP KR US); C12N 2310/531 (2013.01 - US); C12N 2310/533 (2013.01 - EP KR US); C12N 2320/32 (2013.01 - EP KR US); C12N 2320/50 (2013.01 - EP KR US)
Citation (search report)
- [I] JOHN NEMUNAITIS ET AL: "Personalized Cancer Approach: Using RNA Interference Technology", WORLD JOURNAL OF SURGERY ; OFFICIAL JOURNAL OF THE INTERNATIONALSOCIETY OF SURGERY/SOCIÉTÉ INTERNATIONALE DE CHIRURGIE, SPRINGER-VERLAG, NE, vol. 35, no. 8, 10 May 2011 (2011-05-10), pages 1700 - 1714, XP019924633, ISSN: 1432-2323, DOI: 10.1007/S00268-011-1100-0
- See references of WO 2013170071A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
US 2013302407 A1 20131114; US 9353373 B2 20160531; AR 091004 A1 20141230; AU 2013259387 A1 20141120; AU 2013259387 B2 20161215; CA 2872930 A1 20131114; CN 104685055 A 20150603; EP 2847333 A1 20150318; EP 2847333 A4 20151216; IL 235486 A0 20141231; JP 2015521040 A 20150727; JP 2017221198 A 20171221; JP 6283661 B2 20180221; KR 20150006477 A 20150116; MX 2014013475 A 20150515; SG 11201407239S A 20141230; TW 201402813 A 20140116; US 2016333351 A1 20161117; WO 2013170071 A1 20131114
DOCDB simple family (application)
US 201313890957 A 20130509; AR P130101611 A 20130509; AU 2013259387 A 20130509; CA 2872930 A 20130509; CN 201380036406 A 20130509; EP 13788485 A 20130509; IL 23548614 A 20141103; JP 2015511715 A 20130509; JP 2017131718 A 20170705; KR 20147034469 A 20130509; MX 2014013475 A 20130509; SG 11201407239S A 20130509; TW 102116636 A 20130509; US 2013040407 W 20130509; US 201615141280 A 20160428