EP 2849794 A1 20150325 - NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE AND USE OF NMR ANALYSES OF THE SAME
Title (en)
NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE AND USE OF NMR ANALYSES OF THE SAME
Title (de)
NUKLEOPHILE KATALYSATOREN ZUR BINDUNG AN OXIME UND VERWENDUNG VON NMR-ANALYSEN DAFÜR
Title (fr)
CATALYSEUR NUCLÉOPHILE POUR LIAISON OXIME ET UTILISATION DE SES ANALYSES RMN
Publication
Application
Priority
- US 201261647814 P 20120516
- US 201213488043 A 20120604
- US 201313803594 A 20130314
- US 2013041300 W 20130516
Abstract (en)
[origin: WO2013173543A1] The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
IPC 8 full level
A61K 47/48 (2006.01)
CPC (source: EA EP KR)
A61K 47/50 (2017.07 - KR); A61K 47/60 (2017.07 - EA EP); A61K 47/61 (2017.07 - EA EP); A61P 5/00 (2017.12 - EP); A61P 7/04 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 1/1077 (2013.01 - EP); C07K 1/16 (2013.01 - KR); C07K 1/34 (2013.01 - KR); C07K 14/745 (2013.01 - KR); C07K 19/00 (2013.01 - KR)
Citation (search report)
See references of WO 2013173557A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2013173543 A1 20131121; AU 2013204754 B2 20151105; AU 2013204754 C1 20181011; BR 112014028636 A2 20170815; BR 112014028636 B1 20220920; CA 2873756 A1 20131121; CA 2873756 C 20220816; CN 104487095 A 20150401; CN 104487095 B 20181207; CN 109620963 A 20190416; CN 109620963 B 20221028; EA 028186 B1 20171031; EA 028186 B9 20180531; EA 035506 B1 20200625; EA 201492115 A1 20150529; EA 201790935 A1 20171229; EP 2849794 A1 20150325; EP 2849795 A1 20150325; EP 2849795 B1 20220406; EP 4019049 A1 20220629; HK 1209024 A1 20160324; JP 2015520163 A 20150716; JP 2017145260 A 20170824; JP 2019089810 A 20190613; JP 2020111599 A 20200727; JP 2022034075 A 20220302; JP 6195611 B2 20170913; JP 6560712 B2 20190814; JP 6711935 B2 20200617; JP 7014844 B2 20220201; JP 7304402 B2 20230706; KR 102110622 B1 20200514; KR 102237306 B1 20210408; KR 102287040 B1 20210809; KR 102326360 B1 20211115; KR 20150008192 A 20150121; KR 20200053636 A 20200518; KR 20210041629 A 20210415; KR 20210099187 A 20210811; MX 2014013919 A 20150605; MX 360594 B 20181109; NZ 701945 A 20161028; NZ 724828 A 20180223; NZ 738844 A 20181221; NZ 738846 A 20190531; SG 10201701780R A 20170427; SG 10201911328Q A 20200130; SG 11201407597X A 20141230; WO 2013173557 A1 20131121
DOCDB simple family (application)
US 2013041280 W 20130516; AU 2013204754 A 20130412; BR 112014028636 A 20130516; CA 2873756 A 20130516; CN 201380037823 A 20130516; CN 201811295900 A 20130516; EA 201492115 A 20130516; EA 201790935 A 20130516; EP 13724491 A 20130516; EP 13728026 A 20130516; EP 21214357 A 20130516; HK 15109408 A 20150924; JP 2015512831 A 20130516; JP 2017109323 A 20170601; JP 2019018663 A 20190205; JP 2020067396 A 20200403; JP 2021215385 A 20211229; KR 20147035113 A 20130516; KR 20207013096 A 20130516; KR 20217009701 A 20130516; KR 20217024432 A 20130516; MX 2014013919 A 20130516; NZ 70194513 A 20130516; NZ 72482813 A 20130516; NZ 73884413 A 20130516; NZ 73884613 A 20130516; SG 10201701780R A 20130516; SG 10201911328Q A 20130516; SG 11201407597X A 20130516; US 2013041300 W 20130516