Global Patent Index - EP 2851077 A1

EP 2851077 A1 20150325 - Use of nitrogen protoxide for the treatment of chronic dysfunctional pain

Title (en)

Use of nitrogen protoxide for the treatment of chronic dysfunctional pain

Title (de)

Verwendung von Distickstoffmonoxid zur Behandlung von chronischen Schmerzen, die auf Funktionsstörungen zurückgehen

Title (fr)

Utilisation de protoxyde d'azote pour le traitement d'une douleur chronique d'origine dysfunctionnelle

Publication

EP 2851077 A1 20150325 (FR)

Application

EP 14191724 A 20100412

Priority

  • FR 0952807 A 20090429
  • EP 10723653 A 20100412

Abstract (en)

[origin: WO2010125271A1] The invention relates to a gas mixture that contains nitrous oxide (N2O) for use as a breathable drug for the treatment of chronic pain in a mammal, in particular a pain from neuropathic, iatrogenic, dysfunctional or inflammatory origin, in particular in humans. The proportion of N2O ranges from 15 to 45 vol. %. The gas mixture is administered for a sufficient duration for obtaining a delayed pain hypersensitivity reduction that can be observed at least 6 hours after the end of the inhalation of the gas mixture by said mammal. The pain hypersensitivity is selected from allodynias and hyperalgesias.

Abstract (fr)

L'invention porte sur un mélange gazeux contenant une proportion de protoxyde d'azote (N 2 O) comprise entre 15 et 45 % en volume pour une utilisation en tant que médicament inhalable pour le traitement curatif d'une douleur chronique d'origine dysfonctionnelle chez un mammifère, par réduction de l'hypersensibilité à la douleur choisie parmi les allodynies et les hyperalgésies. La douleur d'origine dysfonctionnelle peut être liée à une fibromyalgie, au syndrome du côlon irritable ou à une céphalée.

IPC 8 full level

A61K 33/00 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); A61P 19/02 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/06 (2006.01); A61P 29/00 (2006.01); A61P 29/02 (2006.01)

CPC (source: EP US)

A61K 9/0073 (2013.01 - EP US); A61K 33/00 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 19/02 (2017.12 - EP); A61P 19/04 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 23/00 (2017.12 - EP); A61P 23/02 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 29/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP)

Citation (applicant)

  • BREIVIK,H. ET AL.: "Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment", EUR. J. PAIN, vol. 10, 2006, pages 287 - 333, XP005347256, DOI: doi:10.1016/j.ejpain.2005.06.009
  • T.J. CODERRE ET AL.: "Peripheral and central hyperexeitability: differential signs and symptoms in persistent pain, Behav", BRAIN SCI., vol. 20, 1997, pages 404 - 419
  • C.J. WOOLF ET AL.: "Neuropathic pain: aetiology, symptoms, mechanisms, and management", LANCET, vol. 353, 1999, pages 1959 - 1964, XP005062964, DOI: doi:10.1016/S0140-6736(99)01307-0
  • C.G. PARSONS: "NMDA receptors as targets for drug action in neuropathic pain", EUR. J. PHARMACOL., vol. 429, 2001, pages 71 - 78, XP001076802, DOI: doi:10.1016/S0014-2999(01)01307-3
  • CHIZH,B.A. ET AL.: "NMDA antagonists and neuropathic pain--multiple drug targets and multiple uses", CURR. PHARM. DES, vol. 11, 2005, pages 2977 - 2994
  • J.A. KEMP ET AL.: "NMDA receptor pathways as drug targets", NAT. NEUROSCI., vol. 5, 2002, pages 1039 - 1042, XP002291704, DOI: doi:10.1038/nn936
  • B.A.CHIZH ET AL.: "NMDA receptor antagonists as analgesics: focus on the NR2B subtype", TRENDS PHARMA. SCI., vol. 22, 2001, pages 636 - 642, XP004323807, DOI: doi:10.1016/S0165-6147(00)01863-0
  • D. ANNEQUIN ET AL.: "Fixed 50% nitrous oxide oxygen mixture for painful procedures: A French survey", PEDIATRICS, vol. 105, 2000, pages E47
  • P. ONODY: "Safety of inhalation of a 50% nitrous eoxide/oxygen premix: a prospective survey of 35 828 administrations", DRUG SAF, vol. 29, 2006, pages 633 - 640, XP009127223, DOI: doi:10.2165/00002018-200629070-00008
  • J.T. KNAPE: "Nitrous oxide not unsafe but used less often", NED. TIJDSCHR. GENEESKD., vol. 150, 2006, pages 1053 - 1054
  • S.K GEORGIEV ET AL.: "Nitrous oxide inhibits glutamatergic transmission in spinal dorsal horn neurons", PAIN, vol. 134, 2008, pages 24 - 31, XP022409054, DOI: doi:10.1016/j.pain.2007.03.026
  • P. NAGELE ET AL.: "Nitrous oxide requires the N-methyl-D-aspartate receptor for its action in Caenorhabditis elegans", PROC. NATL. ACAD. SCI. U. S. A, vol. 101, 2004, pages 8791 - 8796
  • V. JEVTOVIC-TODOROVIC ET AL.: "Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin", NAT. MED., vol. 4, 1998, pages 460 - 463, XP008049733, DOI: doi:10.1038/nm0498-460
  • B. BESSIERE. ET AL.: "Nitrous oxide prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats", NEUROPHARMACOLOGY, vol. 53, 2007, pages 733 - 740, XP022293459, DOI: doi:10.1016/j.neuropharm.2007.08.003
  • P. RICHEBE ET AL.: "Nitrous oxide revisited: evidence for potent antihyperalgesic properties", ANESTHESIOLOGY, vol. 103, 2005, pages 845 - 854, XP009108511, DOI: doi:10.1097/00000542-200510000-00024

Citation (search report)

  • [XI] WO 2008139078 A2 20081120 - AIR LIQUIDE [FR], et al
  • [A] US 2009005358 A1 20090101 - LESSEM JAN [US]
  • [X] STANLEY A: "Migraine treated by inhalation sedation using nitrous oxide and oxygen", BRITISH DENTAL JOURNAL,, vol. 149, no. 2, 15 July 1980 (1980-07-15), pages 54, XP009127230, ISSN: 0007-0610
  • [T] MORRIS MAIZELS ET AL: "Beyond Neurovascular: Migraine as a Dysfunctional Neurolimbic Pain Network", HEADACHE, vol. 52, no. 10, 3 November 2012 (2012-11-03), pages 1553 - 1565, XP055169095, ISSN: 0017-8748, DOI: 10.1111/j.1526-4610.2012.02209.x
  • [T] MIRA MEEUS ET AL: "Central Sensitization in Patients with Rheumatoid Arthritis: A Systematic Literature Review", SEMINARS IN ARTHRITIS AND RHEUMATISM, vol. 41, no. 4, 2012, pages 556 - 567, XP028456242, ISSN: 0049-0172, [retrieved on 20110905], DOI: 10.1016/J.SEMARTHRIT.2011.08.001
  • [T] ELIZABETH AMY OLD ET AL: "Chemokine mediated neuronglia communication and aberrant signalling in neuropathic pain states", CURRENT OPINION IN PHARMACOLOGY, vol. 12, no. 1, 2012, pages 67 - 73, XP028458923, ISSN: 1471-4892, [retrieved on 20111018], DOI: 10.1016/J.COPH.2011.10.015
  • [T] STUART M BROOKS: "Irritant-Induced Chronic Cough: Irritant-Induced TRPpathy", LUNG, SPRINGER-VERLAG, US, vol. 186, no. 1, 1 February 2008 (2008-02-01), pages 88 - 93, XP019589562, ISSN: 1432-1750

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DOCDB simple family (publication)

WO 2010125271 A1 20101104; CA 2755780 A1 20101104; EP 2424548 A1 20120307; EP 2851076 A1 20150325; EP 2851077 A1 20150325; FR 2944969 A1 20101105; FR 2944969 B1 20110826; JP 2012525360 A 20121022; US 2012045528 A1 20120223

DOCDB simple family (application)

FR 2010050697 W 20100412; CA 2755780 A 20100412; EP 10723653 A 20100412; EP 14191722 A 20100412; EP 14191724 A 20100412; FR 0952807 A 20090429; JP 2012507797 A 20100412; US 201013318086 A 20100412