Global Patent Index - EP 2863747 A4

EP 2863747 A4 20151223 - NOVEL CABERGOLINE DERIVATIVES

Title (en)

NOVEL CABERGOLINE DERIVATIVES

Title (de)

NEUARTIGE CABERGOLINDERIVATE

Title (fr)

NOUVEAUX DÉRIVÉS DE CABERGOLINE

Publication

EP 2863747 A4 20151223 (EN)

Application

EP 12879191 A 20120622

Priority

US 2012043687 W 20120622

Abstract (en)

[origin: WO2013191704A1] Provided herein are novel cabergoline analogs and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine and Parkinson's disease using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing dopaminergic D2 receptors and/or antagonizing or inhibiting activity of receptors such as the 5-HT2 serotonin receptors using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HTID and/or the 5-HTIB receptor, without agonizing (or very weakly agonising) the 5-HT2B receptor using the compounds and compositions disclosed herein.

IPC 8 full level

A61K 31/44 (2006.01); A61P 25/06 (2006.01); A61P 25/16 (2006.01); C07D 457/04 (2006.01); C07D 457/06 (2006.01)

CPC (source: EP)

A61P 25/00 (2017.12); A61P 25/06 (2017.12); A61P 25/16 (2017.12); C07D 457/04 (2013.01); C07D 457/06 (2013.01)

Citation (search report)

  • [E] WO 2013095708 A1 20130627 - MAP PHARMACEUTICALS INC [US], et al
  • [X] US 7217822 B2 20070515 - COMIN JORGE HUMBERTO ZENON [AR], et al
  • [X] WO 2004069252 A1 20040819 - PHARMACIA ITALIA SPA [IT], et al
  • [X] US 5705510 A 19980106 - DESANTIS JR LOUIS [US], et al
  • [X] WO 2005085243 A2 20050915 - RICHTER GEDEON VEGYESZET [HU], et al
  • [X] WO 9012796 A1 19901101 - SCHERING AG [DE]
  • [X] US 4526892 A 19850702 - SALVATI PATRICIA [IT], et al
  • [X] EP 2067780 A1 20090610 - AXXONIS PHARMA AG [DE]
  • [X] WO 2010081036 A2 20100715 - HARVARD COLLEGE [US], et al
  • [X] CZ 287176 B6 20001011 - GALENA AS [CZ]
  • [XI] A. KEKEWSKA ET AL: "The Bulky N(6) Substituent of Cabergoline Is Responsible for Agonism of This Drug at 5-Hydroxytryptamine (5-HT)2A and 5-HT2B Receptors and Thus Is a Determinant of Valvular Heart Disease", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 338, no. 1, 1 July 2011 (2011-07-01), US, pages 381 - 391, XP055228644, ISSN: 0022-3565, DOI: 10.1124/jpet.111.181255
  • [X] MANTEGANI S ET AL: "Serotonergic ergoline derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 8, no. 9, 1 May 1998 (1998-05-01), pages 1117 - 1122, XP004137031, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(98)00166-8
  • [X] BRAMBILLA E ET AL: "Synthesis and nidation inhibitory activity of a new class of ergoline derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 24, no. 4, 1 July 1989 (1989-07-01), pages 421 - 426, XP023870591, ISSN: 0223-5234, [retrieved on 19890701], DOI: 10.1016/0223-5234(89)90087-1
  • [X] MIYAGI M ET AL: "DOPAMINE RECEPTOR AFFINITIES IN VITRO AND STEREOTYPIC ACTIVITIES IN VIVO OF CABERGOLINE IN RATS", BIOLOGICAL & PHARMACEUTICAL BULLETIN (OF JAPAN), PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 19, no. 9, 1 January 1996 (1996-01-01), pages 1210 - 1213, XP009040256, ISSN: 0918-6158
  • See references of WO 2013191704A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2013191704 A1 20131227; AU 2012382929 A1 20150205; BR 112014031945 A2 20170627; CA 2876321 A1 20131227; CN 104822264 A 20150805; EP 2863747 A1 20150429; EP 2863747 A4 20151223; HK 1208997 A1 20160324; IL 236310 A0 20150226; JP 2015525239 A 20150903; RU 2014153672 A 20160810; SG 11201408567P A 20150227

DOCDB simple family (application)

US 2012043687 W 20120622; AU 2012382929 A 20120622; BR 112014031945 A 20120622; CA 2876321 A 20120622; CN 201280075321 A 20120622; EP 12879191 A 20120622; HK 15109927 A 20151012; IL 23631014 A 20141217; JP 2015518385 A 20120622; RU 2014153672 A 20120622; SG 11201408567P A 20120622