EP 2866819 A1 20150506 - DOSING INSTRUCTIONS FOR ENDOTOXIN-BINDING LIPOPEPTIDES
Title (en)
DOSING INSTRUCTIONS FOR ENDOTOXIN-BINDING LIPOPEPTIDES
Title (de)
DOSIERUNGSANLEITUNG FÜR ENDOTOXINBINDENDE LIPOPEPTIDE
Title (fr)
INSTRUCTIONS DE DOSAGE POUR DES LIPOPEPTIDES SE LIANT AUX ENDOTOXINES
Publication
Application
Priority
- EP 12174285 A 20120629
- EP 2013063496 W 20130627
- EP 13732900 A 20130627
Abstract (en)
[origin: EP2679236A1] Endotoxin-binding lipopeptide comprising polymyxins, polymyxin derivatives, polymyxin analogues, their prodrugs and salts, for preventing or treating diseases and conditions caused by endotoxemia, by (i) parenterally administering a bolus of the lipopeptide to achieve a lipopeptide serum concentration of 0.01-0.8 mu g/ml and (ii) maintaining this lipopeptide serum concentration by parenterally administering the lipopeptide over a predetermined period of time, is claimed. An independent claim is also included for a formulation for parenteral administration comprising the lipopeptide. ACTIVITY : Antibacterial; Antiinflammatory; Immunosuppressive. Test details are described but no results given. MECHANISM OF ACTION : None given.
IPC 8 full level
A61K 38/12 (2006.01); A61P 31/00 (2006.01)
CPC (source: EP US)
A61K 9/0019 (2013.01 - EP US); A61K 38/12 (2013.01 - EP US); A61P 31/00 (2017.12 - EP)
Citation (search report)
See references of WO 2014001444A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 2679236 A1 20140101; EP 2866819 A1 20150506; US 2015190461 A1 20150709; WO 2014001444 A1 20140103
DOCDB simple family (application)
EP 12174285 A 20120629; EP 13732900 A 20130627; EP 2013063496 W 20130627; US 201314411879 A 20130623