EP 2872130 A1 20150520 - SELECTIVE INHIBITION OF THE MEMBRANE ATTACK COMPLEX OF COMPLEMENT AND C3 CONVERTASE BY LOW MOLECULAR WEIGHT COMPONENTS OF THE AURIN TRICARBOXYLIC ACID SYNTHETIC COMPLEX
Title (en)
SELECTIVE INHIBITION OF THE MEMBRANE ATTACK COMPLEX OF COMPLEMENT AND C3 CONVERTASE BY LOW MOLECULAR WEIGHT COMPONENTS OF THE AURIN TRICARBOXYLIC ACID SYNTHETIC COMPLEX
Title (de)
SELEKTIVE HEMMUNG DES MEMBRANANGRIFFSKOMPLEXES DES KOMPLEMENTS UND DER C3-KONVERTASE DURCH NIEDRIGMOLEKULARE KOMPONENTEN DES SYNTHETISCHEN AURIN-TRICARBONSÄURE-KOMPLEXES
Title (fr)
INHIBITION SÉLECTIVE DU COMPLEXE D'ATTAQUE MEMBRANAIRE DU COMPLÉMENT ET DE LA C3 CONVERTASE PAR DES COMPOSANTS À FAIBLE POIDS MOLÉCULAIRE DU COMPLEXE SYNTHÉTIQUE D'ACIDE PARAROSOLIQUE TRICARBOXYLIQUE
Publication
Application
Priority
IB 2012053608 W 20120713
Abstract (en)
[origin: WO2014009779A1] Selective inhibition of the membrane attack complex of complement in a mammalian species, preferably human, with components of the aurin tricarboxylic acid complex of less than 1 kilodalton in molecular weight. Preferred inhibitors are aurin tricarboxylic acid, aurin quadracarboxylic acid and aurin hexacarboxylic acid. Preferred disease to be treated by elective inhibition of the membrane attack complex of complement are age-related macular degeneration, Alzheimer's disease, atherosclerosis, rheumatoid arthritis, paroxysmal nocturnal hemoglobinemia, malaria infection and multiple sclerosis.
IPC 8 full level
A61K 31/194 (2006.01); A61P 37/02 (2006.01); C12N 9/64 (2006.01)
CPC (source: EP)
A61K 31/194 (2013.01); A61P 9/10 (2017.12); A61P 13/12 (2017.12); A61P 19/02 (2017.12); A61P 25/00 (2017.12); A61P 25/28 (2017.12); A61P 27/02 (2017.12); A61P 29/00 (2017.12); A61P 37/02 (2017.12); A61P 43/00 (2017.12); C12N 9/6424 (2013.01); C12Y 304/21043 (2013.01); Y02A 50/30 (2017.12)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2014009779 A1 20140116; CA 2878734 A1 20140116; CA 2878734 C 20210427; CN 104661660 A 20150527; EP 2872130 A1 20150520; EP 2872130 A4 20160622; JP 2015522060 A 20150803
DOCDB simple family (application)
IB 2012053608 W 20120713; CA 2878734 A 20120713; CN 201280075715 A 20120713; EP 12880850 A 20120713; JP 2015521077 A 20120713