EP 2876166 A1 20150527 - New compound for sequencing by synthesis

Title (en)

New compound for sequencing by synthesis

Title (de)

Neue Verbindungen für Sequencing-by-Synthesis

Title (fr)

Nouveaux composés pour le séquençage par synthèse

Publication

EP 2876166 A1 20150527 (EN)

Application

EP 13193588 A 20131120

Priority

EP 13193588 A 20131120

Abstract (en)

The present invention provides deoxynucleoside tri - or tetraphosphate comprising a 3' nitrate and a detectable label covalently bound to the oxygen atom of a oxymethyl or oxyallyl or oxypropargyl substitution of a nucleobase. Such compounds provide new possibilities for future Sequencing by Synthesis technologies.

IPC 8 full level

C12Q 1/68 (2006.01); C07H 19/06 (2006.01); C07H 19/10 (2006.01); C07H 19/16 (2006.01); C07H 19/20 (2006.01)

CPC (source: EP US)

C07H 19/10 (2013.01 - EP US); C07H 19/20 (2013.01 - EP US); C12Q 1/6869 (2013.01 - EP US)

C-Set (source: EP US)

C12Q 1/6869 + C12Q 2525/186

Citation (applicant)

WO 9106678 A1 19910516 - STANFORD RES INST INT [US], et al
US 5990300 A 19991123 - HIATT ANDREW C [US], et al
US 2007117104 A1 20070524 - BUZBY PHILIP R [US]
US 2007166705 A1 20070719 - MILTON JOHN [GB], et al
US 2006160081 A1 20060720 - MILTON JOHN [GB], et al
US 7057026 B2 20060606 - BARNES COLIN [GB], et al
DE 2160104 A1 19730322 - HOFFMANN LA ROCHE
DE 2606532 A1 19760826 - HOFFMANN LA ROCHE
WO 9405797 A1 19940317 - KISELEV VSEVOLOD [RU], et al
US 2003134276 A1 20030717 - KILGER CHRISTIAN [DE], et al
US 2008138804 A1 20080612 - BUZBY PHILIP R [US]
EP 0747447 A2 19961211 - BOEHRINGER MANNHEIM GMBH [DE]
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Citation (search report)

[YD] US 2007117104 A1 20070524 - BUZBY PHILIP R [US]
[AD] DE 2160104 A1 19730322 - HOFFMANN LA ROCHE
[AD] US 2008138804 A1 20080612 - BUZBY PHILIP R [US]
[AD] US 5990300 A 19991123 - HIATT ANDREW C [US], et al
[A] WO 2006074351 A2 20060713 - AGENCOURT BIOSCIENCE CORP [US], et al
[YD] NAIMI E ET AL: "Synthesis of 3'- and 5'-Nitrooxy Pyrimidine Nucleoside Nitrate Esters: Nitric Oxide Donor Agents for Evaluation as Anticancer and Antiviral Agents", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 46, 1 January 2003 (2003-01-01), pages 995 - 1004, XP003015627, ISSN: 0022-2623, DOI: 10.1021/JM020299R
[A] R. DUSCHINSKY ET AL: "Nitric acid esters of pyrimidine nucleosides", TETRAHEDRON LETTERS, vol. 8, no. 50, 1 January 1967 (1967-01-01), pages 5103 - 5108, XP055094643, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(01)89925-1
[A] J. WU ET AL: "3'-O-modified nucleotides as reversible terminators for pyrosequencing", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 104, no. 42, 1 October 2007 (2007-10-01), pages 16462 - 16467, XP055013820, ISSN: 0027-8424, DOI: 10.1073/pnas.0707495104
[A] CANARD B ET AL: "DNA polymerase fluorescent substrates with reversible 3'-tags", GENE, ELSEVIER, AMSTERDAM, NL, vol. 148, no. 1, 11 October 1994 (1994-10-11), pages 1 - 6, XP023787574, ISSN: 0378-1119, [retrieved on 19941011], DOI: 10.1016/0378-1119(94)90226-7
[A] RAMANATHAN A ET AL: "High-density polymerase-mediated incorporation of fluorochrome-labeled nucleotides", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, vol. 337, no. 1, 1 February 2005 (2005-02-01), pages 1 - 11, XP004707202, ISSN: 0003-2697, DOI: 10.1016/J.AB.2004.09.043

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 2876166 A1 20150527; EP 2876166 B1 20161214; US 2015140561 A1 20150521; US 9410197 B2 20160809

DOCDB simple family (application)

EP 13193588 A 20131120; US 201414542980 A 20141117