EP 2877176 B1 20170426 - DERIVATIVES OF AZAINDAZOLE OR DIAZAINDAZOLE TYPE FOR TREATING A CANCER OVEREXPRESSING TRK
Title (en)
DERIVATIVES OF AZAINDAZOLE OR DIAZAINDAZOLE TYPE FOR TREATING A CANCER OVEREXPRESSING TRK
Title (de)
AZAINDAZOL- ODER DIAZAINDAZOL-DERIVATE ZUR BEHANDLUNG EINES KREBSES, DER TRK ÜBEREXPRIMIERT
Title (fr)
DÉRIVÉS DE TYPE AZAINDAZOLE OU DIAZAINDAZOLE POUR TRAITER UN CANCER SUREXPRIMANT LA TRK
Publication
Application
Priority
- EP 12305926 A 20120727
- EP 2013065913 W 20130729
- EP 13741791 A 20130729
Abstract (en)
[origin: EP2689779A1] The present invention relates to a compound of following formula (I): or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture, as well as pharmaceutical composition comprising such a compound, for use in the treatment of a cancer associated with the overexpression of at least one Trk protein.
IPC 8 full level
A61K 31/437 (2006.01); A61K 31/4985 (2006.01); A61K 31/5025 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61K 31/437 (2013.01 - EP US); A61K 31/496 (2013.01 - EP US); A61K 31/4985 (2013.01 - EP US); A61K 31/5025 (2013.01 - EP US); A61K 31/519 (2013.01 - EP US); A61K 45/06 (2013.01 - US); A61P 35/00 (2017.12 - EP); C07D 471/04 (2013.01 - EP US); C07D 487/04 (2013.01 - EP US)
Citation (examination)
- J.- C. SORIA ET AL: "Added value of molecular targeted agents in oncology", ANNALS OF ONCOLOGY., vol. 22, no. 8, 7 February 2011 (2011-02-07), NL, pages 1703 - 1716, XP055286578, ISSN: 0923-7534, DOI: 10.1093/annonc/mdq675
- HIROYUKI FUJIKAWA ET AL: "High TrkB expression levels are associated with poor prognosis and EMT induction in colorectal cancer cells", JOURNAL OF GASTROENTEROLOGY, SPRINGER-VERLAG, TO, vol. 47, no. 7, 24 February 2012 (2012-02-24), pages 775 - 784, XP035087284, ISSN: 1435-5922, DOI: 10.1007/S00535-012-0532-0
- YINGJIAO YU ET AL: "Overexpression of TrkB promotes the progression of colon cancer", APMIS, vol. 118, no. 3, 1 March 2010 (2010-03-01), DK, pages 188 - 195, XP055286460, ISSN: 0903-4641, DOI: 10.1111/j.1600-0463.2009.02577.x
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 2689779 A1 20140129; EP 2877176 A1 20150603; EP 2877176 B1 20170426; ES 2634314 T3 20170927; HU E033796 T2 20180129; PL 2877176 T3 20171031; US 2015266880 A1 20150924; US 9428510 B2 20160830; WO 2014016434 A1 20140130
DOCDB simple family (application)
EP 12305926 A 20120727; EP 13741791 A 20130729; EP 2013065913 W 20130729; ES 13741791 T 20130729; HU E13741791 A 20130729; PL 13741791 T 20130729; US 201314417532 A 20130729