EP 2885313 A4 20160309 - POLYNUCLEOTIDES HAVING BIOREVERSIBLE GROUPS

Title (en)

POLYNUCLEOTIDES HAVING BIOREVERSIBLE GROUPS

Title (de)

POLYNUKLEOTIDE MIT BIOREVERSIBLEN GRUPPEN

Title (fr)

POLYNUCLÉOTIDES POSSÉDANT DES GROUPES BIORÉVERSIBLES

Publication

EP 2885313 A4 20160309 (EN)

Application

EP 13831273 A 20130820

Priority

US 201261691175 P 20120820
US 2013055675 W 20130820

Abstract (en)

[origin: WO2014031575A1] The disclosure provides methods and compositions for delivering polynucleotides into cells. The disclosure provides transiently protected polynucleotides comprising an anionic charge- neutralizing moiety/group, which may also confer additional functionality. These compounds can enter the cytosol of cells by endocytic or macropinocytic mechanisms. The transient protecting group is bioreversible, i.e., once inside a cell, it is designed to be removed by enzymatic activity or by passive intracellular methods (e.g., changes in pH or reductive environment).

IPC 8 full level

C07H 21/00 (2006.01); A61K 31/713 (2006.01); C07H 19/04 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01)

CPC (source: EP US)

A61K 31/7125 (2013.01 - EP US); A61K 31/713 (2013.01 - EP US); A61K 47/645 (2017.07 - EP US); A61P 43/00 (2017.12 - EP); C07H 21/00 (2013.01 - EP US); C07H 21/02 (2013.01 - EP US); C12N 15/111 (2013.01 - EP US); C12N 15/113 (2013.01 - US); C12N 2310/14 (2013.01 - US); C12N 2310/351 (2013.01 - EP US); C12N 2320/32 (2013.01 - EP US); C12N 2810/40 (2013.01 - US); Y02P 20/55 (2015.11 - EP US)

Citation (search report)

[X] WO 2011005761 A1 20110113 - ONTORII INC [US], et al
[X] WO 9807734 A1 19980226 - HYBRIDON INC [US]
[X] US 6399589 B1 20020604 - GOSSELIN GILLES [FR], et al
[X] US 6124445 A 20000926 - IMBACH JEAN-LOUIS [FR], et al
See references of WO 2014031575A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2014031575 A1 20140227; AU 2013306006 A1 20150226; AU 2013306006 B2 20170706; CA 2880869 A1 20140227; CN 104781271 A 20150715; CN 104781271 B 20180706; EP 2885313 A1 20150624; EP 2885313 A4 20160309; HK 1208682 A1 20160311; IN 1765DEN2015 A 20150529; JP 2015529073 A 20151005; US 2015238516 A1 20150827; US 2018303864 A1 20181025; US 9950001 B2 20180424

DOCDB simple family (application)

US 2013055675 W 20130820; AU 2013306006 A 20130820; CA 2880869 A 20130820; CN 201380054525 A 20130820; EP 13831273 A 20130820; HK 15109270 A 20150921; IN 1765DEN2015 A 20150303; JP 2015528564 A 20130820; US 201314422970 A 20130820; US 201815954153 A 20180416