EP 2889377 A1 20150701 - FCYRIIB-SPECIFIC FC REGION VARIANT
Title (en)
FCYRIIB-SPECIFIC FC REGION VARIANT
Title (de)
FCYRIIB-SPEZIFISCHE FC-REGIONSVARIANTE
Title (fr)
VARIANT DE LA RÉGION FC SPÉCIFIQUE À FCYRIIB
Publication
Application
Priority
- JP 2012185868 A 20120824
- JP 2013072507 W 20130823
Abstract (en)
An objective of the present invention is to provide an Fc region variant with enhanced Fc³RIIb-binding activity, and/or enhanced binding selectivity to Fc³RIIb compared to Fc³RIIa (type R), as compared to those of a polypeptide containing an Fc region to which an amino acid alteration(s) has not been introduced; a polypeptide which includes the Fc region variant; a pharmaceutical composition containing the polypeptide; preventing therapeutic or preventive agent for immunological inflammatory diseases that includes the pharmaceutical composition; a production method thereof; and a method of enhancing Fc³RIIb-binding activity and also enhancing binding selectivity to Fc³RIIb compared to Fc³RIIa (type R). It was found that a polypeptide containing an antibody Fc region variant that contains an amino acid sequence in which an amino-acid alteration at position 238 (EU numbering) is combined with other specific amino-acid alterations enhances Fc³RIIb-binding activity, and/or enhances binding selectivity to Fc³RIIb compared to Fc³RIIa (type R).
IPC 8 full level
A61K 39/00 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01)
CPC (source: EP IL KR RU US)
A61K 9/0019 (2013.01 - RU); A61P 29/00 (2018.01 - EP IL); A61P 43/00 (2018.01 - EP IL); C07K 16/00 (2013.01 - EP IL RU US); C07K 16/28 (2013.01 - IL KR RU US); C07K 16/2866 (2013.01 - EP IL RU US); C07K 16/303 (2013.01 - EP IL RU US); C07K 16/46 (2013.01 - KR); C07K 19/00 (2013.01 - KR); A61K 9/0019 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP IL KR US); C07K 2317/52 (2013.01 - EP IL KR US); C07K 2317/524 (2013.01 - EP IL US); C07K 2317/53 (2013.01 - EP IL US); C07K 2317/71 (2013.01 - EP IL US); C07K 2317/72 (2013.01 - EP IL US); C07K 2317/92 (2013.01 - KR US); C07K 2317/94 (2013.01 - EP IL US); C07K 2319/30 (2013.01 - US); Y02A 50/30 (2018.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 2889377 A1 20150701; EP 2889377 A4 20160803; EP 2889377 B1 20200108; AU 2013306700 A1 20150212; AU 2013306700 B2 20190502; BR 112015001955 A2 20171107; CA 2882272 A1 20140227; CA 2882272 C 20230829; CN 104736706 A 20150624; CN 104736706 B 20211019; CN 113831406 A 20211224; DK 2889377 T3 20200330; EP 3721900 A1 20201014; ES 2776681 T3 20200731; HK 1208490 A1 20160304; IL 237132 A0 20150331; IL 237132 B 20210531; JP 2019116475 A 20190718; JP 2022024153 A 20220208; JP 2023154045 A 20231018; JP 6501521 B2 20190417; JP 7308039 B2 20230713; JP WO2014030728 A1 20160808; KR 102273985 B1 20210706; KR 20150045443 A 20150428; KR 20210084688 A 20210707; KR 20230110836 A 20230725; MX 2015002368 A 20150603; MX 371442 B 20200130; NZ 705370 A 20180629; RU 2015110250 A 20161020; RU 2729831 C2 20200812; SG 10201709559P A 20171228; SG 11201500873X A 20150429; TW 201420604 A 20140601; TW 201825521 A 20180716; TW 202112809 A 20210401; TW 202237660 A 20221001; TW 202340236 A 20231016; TW I697501 B 20200701; TW I717591 B 20210201; TW I766493 B 20220601; US 10919953 B2 20210216; US 2015299296 A1 20151022; US 2021261648 A1 20210826; WO 2014030728 A1 20140227
DOCDB simple family (application)
EP 13831250 A 20130823; AU 2013306700 A 20130823; BR 112015001955 A 20130823; CA 2882272 A 20130823; CN 201380054911 A 20130823; CN 202111129795 A 20130823; DK 13831250 T 20130823; EP 20150500 A 20130823; ES 13831250 T 20130823; HK 15108960 A 20150914; IL 23713215 A 20150205; JP 2013072507 W 20130823; JP 2014531676 A 20130823; JP 2019013833 A 20190130; JP 2021194096 A 20211130; JP 2023131890 A 20230814; KR 20157004559 A 20130823; KR 20217020493 A 20130823; KR 20237024040 A 20130823; MX 2015002368 A 20130823; NZ 70537013 A 20130823; RU 2015110250 A 20130823; SG 10201709559P A 20130823; SG 11201500873X A 20130823; TW 102130172 A 20130823; TW 107109832 A 20130823; TW 109145681 A 20130823; TW 111104886 A 20130823; TW 111150847 A 20130823; US 201314423269 A 20130823; US 202017028210 A 20200922