EP 2893027 B1 20161019 - IMPROVED MATRIX STABILITY COMPOSITIONS AND METHODS
Title (en)
IMPROVED MATRIX STABILITY COMPOSITIONS AND METHODS
Title (de)
ZUSAMMENSETZUNGEN MIT VERBESSERTER MATRIXSTABILITÄT UND VERFAHREN DAFÜR
Title (fr)
COMPOSITIONS ET PROCÉDÉS DE STABILITÉ AMÉLIORÉE DE MATRICE
Publication
Application
Priority
- US 201261697535 P 20120906
- EP 2013068238 W 20130904
Abstract (en)
[origin: WO2014037372A1] A method for improving the stability of a biosensor test element with respect to degradation by humidity in the air. To a reagent matrix on a test element with working and counter electrodes is provided a deliquescent material selected and in an amount effective to decrease the sorption of water from the air by other components of the reagent matrix. When the test element is a glucose test strip, and the reagent matrix includes a glucose dehydrogenase enzyme (GDH) a flavin adenine dinucleotide cofactor (FAD), a nitrosoaniline mediator, and a film former comprising polyvinylpyrrolidone (PVP), the deliquescent material may include a salt such as NaCl in an amount effective to absorb water from the atmosphere at a rate that is faster than the rate at which the other components of the reagent matrix absorb water from the atmosphere. The above method finds particular utility in use with reagent mixtures, such as the reagent mixture of a glucose biosensor, that lose their function or are unstable under high humidity conditions resulting in strip failure or biased results (e.g., when vials of glucose strips are open for extended time in steamy rooms or tropical conditions). The present invention provides an improvement in glucose strip stability under such conditions, by adding a new component to the reagent matrix that reduces the water sorption properties and consequently does not create the environment for active component degradation to occur.
IPC 8 full level
G01N 27/327 (2006.01); C12Q 1/00 (2006.01)
CPC (source: EP KR US)
C12Q 1/004 (2013.01 - EP KR US); G01N 27/3272 (2013.01 - US); G01N 27/3274 (2013.01 - US); G01N 33/62 (2013.01 - KR); Y10T 29/49002 (2015.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2014037372 A1 20140313; CA 2880321 A1 20140313; CA 2880321 C 20170411; CN 106170555 A 20161130; CN 106170555 B 20191022; EP 2893027 A1 20150715; EP 2893027 B1 20161019; ES 2603928 T3 20170302; HK 1231520 A1 20171222; JP 2015527590 A 20150917; JP 6194001 B2 20170906; KR 102005139 B1 20190729; KR 20150052868 A 20150514; KR 20160088950 A 20160726; PL 2893027 T3 20170331; US 2015177178 A1 20150625; US 9459230 B2 20161004
DOCDB simple family (application)
EP 2013068238 W 20130904; CA 2880321 A 20130904; CN 201380045028 A 20130904; EP 13758850 A 20130904; ES 13758850 T 20130904; HK 17105297 A 20170525; JP 2015530370 A 20130904; KR 20157008689 A 20130904; KR 20167019099 A 20130904; PL 13758850 T 20130904; US 201514639621 A 20150305