EP 2897607 B1 20171122 - INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER
Title (en)
INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER
Title (de)
BETA-HYDROLASE-HEMMER ZUR BEHANDLUNG VON KREBS
Title (fr)
INHIBITEURS DE BÊTA-HYDROLASE POUR LE TRAITEMENT DU CANCER
Publication
Application
Priority
- US 201261704014 P 20120921
- US 2013061050 W 20130920
Abstract (en)
[origin: WO2014047447A2] The present invention relates to compounds which modulate the level or activity of polypeptides having Fe(II) and 2-oxoglutarate (2QG)-dependent oxygenase activity in a cell, tissue, or subject, exemplified by the Fat Mass and Obesity Associated protein (FTO). Aspects relate to N-(3,4-dihydroxy-5-aryl-2-furanyl)-sulfonamides, methods for their synthesis, and methods of using these compounds to modulate the activity of FTO in a cell-free sample, a cell-based assay, and in a subject. Aspects are also directed to compositions comprising compounds which modulate the activity of FTO, including pharmaceutically-acceptable compositions, and to methods of preventing, ameliorating, or treating FTO-mediated conditions or diseases in a subject, including stroke, epilepsy, depression, and degenerative central nervous system disorders such as Alzheimer's and Parkinson's disease. Other aspects elate to use of the compounds to ameliorate or treat conditions associated with metabolic disorders, such as diabetes and obesity.
IPC 8 full level
A61K 31/341 (2006.01); A61P 35/00 (2006.01); C07D 307/32 (2006.01); C07D 307/66 (2006.01); C07D 405/12 (2006.01); C07D 409/04 (2006.01); C07D 417/04 (2006.01)
CPC (source: EP US)
A61P 35/00 (2017.12 - EP US); C07D 307/32 (2013.01 - EP US); C07D 307/66 (2013.01 - EP US); C07D 405/04 (2013.01 - EP US); C07D 405/12 (2013.01 - EP US); C07D 409/04 (2013.01 - EP US); C07D 417/04 (2013.01 - EP US); C12Q 1/26 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2014047447 A2 20140327; WO 2014047447 A3 20150730; AU 2013317791 A1 20150507; AU 2013317791 B2 20180510; CA 2885762 A1 20140327; CA 2885762 C 20220503; CN 104902889 A 20150909; CN 110818660 A 20200221; CN 110818660 B 20230912; EP 2897607 A2 20150729; EP 2897607 A4 20161005; EP 2897607 B1 20171122; EP 3345596 A2 20180711; EP 3345596 A3 20181003; EP 3345596 B1 20210120; ES 2660822 T3 20180326; ES 2865412 T3 20211015; HK 1208805 A1 20160318; JP 2015531351 A 20151102; JP 6469009 B2 20190213; KR 102137180 B1 20200724; KR 20150079616 A 20150708; US 10106532 B2 20181023; US 10351555 B2 20190716; US 10710995 B2 20200714; US 10787445 B2 20200929; US 2015210677 A1 20150730; US 2018009798 A1 20180111; US 2018237427 A1 20180823; US 2019002453 A1 20190103; US 2019300519 A1 20191003; US 2020361925 A1 20201119; US 2021032233 A1 20210204; US 2022251076 A1 20220811; US 9771356 B2 20170926; WO 2014047519 A2 20140327; WO 2014047519 A3 20140530
DOCDB simple family (application)
US 2013060934 W 20130920; AU 2013317791 A 20130920; CA 2885762 A 20130920; CN 201380061004 A 20130920; CN 201910949656 A 20130920; EP 13838498 A 20130920; EP 17202827 A 20130920; ES 13838498 T 20130920; ES 17202827 T 20130920; HK 15109523 A 20150929; JP 2015533237 A 20130920; KR 20157010188 A 20130920; US 2013061050 W 20130920; US 201314430101 A 20130920; US 201715651842 A 20170717; US 201715715989 A 20170926; US 201816131275 A 20180914; US 201916439253 A 20190612; US 202016890680 A 20200602; US 202017029127 A 20200923; US 202217720472 A 20220414