EP 2899202 B1 20180912 - New fusion gene as therapeutic target in proliferative diseases
Title (en)
New fusion gene as therapeutic target in proliferative diseases
Title (de)
Neues Fusionsgen als therapeutisches Target bei proliferativen Erkrankungen
Title (fr)
Nouveau gène de fusion utilisé comme cible thérapeutique dans des maladies prolifératives
Publication
Application
Priority
EP 14152417 A 20140124
Abstract (en)
[origin: EP2899202A1] The present invention relates to a new fusion gene, KIAA0368-ROB02, and the use thereof in methods for diagnosing cancer, in particular a glioblastoma in a subject, wherein the presence and/or expression of said fusion gene in a sample derived from said subject is determined, and wherein the presence or expression of said fusion gene is attributed to the presence of a glioblastoma in said patient. Also methods for the identification of compounds useful in the medical intervention of glioma, in particular glioblastoma, are provided. Accordingly, the present invention also relates to diagnostic means as well as to the medical intervention in cancer, like glioma and in particular glioblastoma. The invention further relates to the use of the fusion gene for diagnosing and/monitoring of tumor progression, preferably of the progression of brain tumors, as well as for the subclassification of brain tumors and other proliferative diseases. The invention further provides a method for determining whether a subject suffering from a proliferative disease is susceptible to treatment with an inhibitor of the activity of the KIAA0368-ROB02 fusion protein.
IPC 8 full level
C07K 14/47 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP US)
C07K 14/4748 (2013.01 - EP US); C07K 16/40 (2013.01 - US); C12Q 1/485 (2013.01 - US); C12Q 1/6886 (2013.01 - US); G01N 33/57407 (2013.01 - EP US); G01N 33/57484 (2013.01 - EP US); C07K 2319/00 (2013.01 - US); C12Q 2600/158 (2013.01 - US); G01N 2500/04 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 2899202 A1 20150729; EP 2899202 B1 20180912; CA 2937041 A1 20150730; US 10077479 B2 20180918; US 2016340738 A1 20161124; WO 2015110538 A1 20150730
DOCDB simple family (application)
EP 14152417 A 20140124; CA 2937041 A 20150122; EP 2015051268 W 20150122; US 201515114003 A 20150122