EP 2906710 A2 20150819 - PROCESS FOR PRODUCING GOUGEROTIN EMPLOYING STREPTOMYCES MICROFLAVUS STRAINS
Title (en)
PROCESS FOR PRODUCING GOUGEROTIN EMPLOYING STREPTOMYCES MICROFLAVUS STRAINS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON GOUGEROTIN MIT STREPTOMYCES MICROFLAVUS-STÄMMEN
Title (fr)
PROCÉDÉ DE PRODUCTION DE LA GOUGEROTINE EN UTILISANT DES SOUCHES DE STREPTOMYCES MICROFLAVUS
Publication
Application
Priority
- US 201261712626 P 20121011
- US 201261714267 P 20121016
- US 201261718674 P 20121025
- US 201261734541 P 20121207
- US 201361759955 P 20130201
- US 201361759977 P 20130201
- EP 13154355 A 20130207
- US 201361879601 P 20130918
- US 2013064537 W 20131011
- EP 13785692 A 20131011
Abstract (en)
[origin: US2014105862A1] The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin. The invention also relates to a method of producing a fermentation broth of a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin, the method comprising cultivating the Streptomyces strain in a culture medium containing a digestible carbon source and a digestible nitrogen source under aerobic conditions, wherein the culture medium contains an amino acid at a concentration effective to achieve a gougerotin concentration of at least 1 g/L. The present disclosure also relates to the molecular cloning of a gougerotin biosynthetic gene cluster from Streptomyces microflavus, and identification of individual genes in the gene cluster as well as the proteins encoded thereby. A gougerotin gene cluster comprising 13 open reading frames (ORFs) is located within a genetic locus of Streptomyces microflavus.
IPC 8 full level
C12P 19/38 (2006.01); A01N 43/54 (2006.01); A01N 63/28 (2020.01); C07H 19/06 (2006.01)
CPC (source: EP US)
A01N 43/54 (2013.01 - US); A01N 63/28 (2020.01 - EP US); C12P 19/28 (2013.01 - EP US); C12P 19/385 (2013.01 - EP US)
Citation (search report)
See references of WO 2014059275A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
US 2014105862 A1 20140417; AU 2013329026 A1 20150402; BR 112015008045 A2 20171128; CN 104968794 A 20151007; EP 2765200 A1 20140813; EP 2906710 A2 20150819; JP 2015534950 A 20151207; KR 20150071011 A 20150625; MX 2015004401 A 20151026; PE 20151080 A1 20150807; TW 201438582 A 20141016; WO 2014059275 A2 20140417; WO 2014059275 A3 20141030
DOCDB simple family (application)
US 201314052094 A 20131011; AU 2013329026 A 20131011; BR 112015008045 A 20131011; CN 201380053082 A 20131011; EP 13154355 A 20130207; EP 13785692 A 20131011; JP 2015536935 A 20131011; KR 20157009064 A 20131011; MX 2015004401 A 20131011; PE 2015000480 A 20131011; TW 102136778 A 20131011; US 2013064537 W 20131011