EP 2910568 A2 20150826 - Methods and compositions for generation of BAX- and BAK-deficient cell lines

Title (en)

Methods and compositions for generation of BAX- and BAK-deficient cell lines

Title (de)

Verfahren und Zusammensetzungen zur Erzeugung von BAX- und BAK-Mangel-Zelllinien

Title (fr)

Procédés et composicions pour la génération de lignées cellulaires déficientes en BAX et BAK

Publication

EP 2910568 A2 20150826 (EN)

Application

EP 15151636 A 20090610

Priority

US 13157908 P 20080610
US 13379208 P 20080702
EP 09762887 A 20090610
US 2009003484 W 20090610

Abstract (en)

Disclosed herein are methods and compositions for generation of Bak- and/or Bax-deficient cell lines using engineered nucleases.

IPC 8 full level

C07K 14/47 (2006.01); C12N 9/22 (2006.01); C12N 15/62 (2006.01)

CPC (source: EP KR US)

C07K 19/00 (2013.01 - KR); C12N 5/0018 (2013.01 - EP KR US); C12N 5/10 (2013.01 - KR); C12N 9/22 (2013.01 - EP KR US); C12N 15/11 (2013.01 - KR); C12N 15/63 (2013.01 - KR); C07K 2319/81 (2013.01 - EP US); C12N 2501/48 (2013.01 - EP KR US); C12N 2510/02 (2013.01 - EP US)

Citation (applicant)

US 2003091982 A1 20030515 - ZONG WEI-XING [US], et al
US 2006063231 A1 20060323 - LI XIAO-YONG [US], et al
US 2008015164 A1 20080117 - COLLINGWOOD TREVOR [US]
WO 2007139982 A2 20071206 - SANGAMO BIOSCIENCES INC [US], et al
US 6140081 A 20001031 - BARBAS CARLOS F [US]
US 6453242 B1 20020917 - EISENBERG STEPHEN P [US], et al
US 6534261 B1 20030318 - COX III GEORGE NORBERT [US], et al
WO 9853058 A1 19981126 - MEDICAL RES COUNCIL [GB], et al
WO 9853059 A1 19981126 - MEDICAL RES COUNCIL [GB], et al
WO 9853060 A1 19981126 - MEDICAL RES COUNCIL [GB], et al
WO 0216536 A1 20020228 - KAO CORP [JP], et al
WO 03016496 A2 20030227 - SCRIPPS RESEARCH INST [US], et al
US 5789538 A 19980804 - REBAR EDWARD J [US], et al
US 5925523 A 19990720 - DOVE SIMON [US], et al
US 6007988 A 19991228 - CHOO YEN [SG], et al
US 6013453 A 20000111 - CHOO YEN [SG], et al
US 6200759 B1 20010313 - DOVE SIMON [US], et al
WO 9519431 A1 19950720 - SCRIPPS RESEARCH INST [US], et al
WO 9606166 A1 19960229 - MEDICAL RES COUNCIL [GB], et al
WO 9853057 A1 19981126 - MEDICAL RES COUNCIL [GB], et al
WO 9854311 A1 19981203 - SCRIPPS RESEARCH INST [US], et al
WO 0027878 A1 20000518 - GENDAQ LTD [GB], et al
WO 0160970 A2 20010823 - TOOLGEN INC [KR]
WO 0188197 A2 20011122 - MASSACHUSETTS INST TECHNOLOGY [US]
WO 02099084 A2 20021212 - SANGAMO BIOSCIENCES INC [US], et al
US 30498105 A 20051215
US 5176996 A 19930105 - HOGAN MICHAEL E [US], et al
US 5422251 A 19950606 - FRESCO JACQUES R [US]
US 5585245 A 19961217 - JOHNSSON NILS [US], et al
WO 9844350 A1 19981008 - UNIV LELAND STANFORD JUNIOR [US]
US 4816567 A 19890328 - CABILLY SHMUEL [US], et al
GB 2276169 A 19940921 - CELLTECH LTD [GB]
US 6453242 B1 20020917 - EISENBERG STEPHEN P [US], et al
US 6534261 B1 20030318 - COX III GEORGE NORBERT [US], et al
US 6410248 B1 20020625 - GREISMAN HARVEY A [US], et al
US 6140466 A 20001031 - BARBAS III CARLOS F [US], et al
US 6242568 B1 20010605 - BARBAS III CARLOS F [US], et al
WO 9837186 A1 19980827 - ACTINOVA LTD [GB], et al
GB 2338237 A 19991215 - ACTINOVA LTD [GB]
WO 02077227 A2 20021003 - SANGAMO BIOSCIENCES INC [US], et al
US 2005064474 A1 20050324 - URNOV FYODOR [US], et al
US 2006188987 A1 20060824 - GUSCHIN DMITRY [US], et al
US 6479626 B1 20021112 - KIM JIN-SOO [KR], et al
US 6903185 B2 20050607 - KIM JIN-SOO [KR], et al
US 7153949 B2 20061226 - KIM JIN-SOO [KR], et al
US 5356802 A 19941018 - CHANDRASEGARAN SRINIVASAN [US]
US 5436150 A 19950725 - CHANDRASEGARAN SRINIVASAN [US]
US 5487994 A 19960130 - CHANDRASEGARAN SRINIVASAN [US]
WO 2007014275 A2 20070201 - SANGAMO BIOSCIENCES INC [US], et al
US 80585007 A 20070523
WO 2007139898 A2 20071206 - SANGAMO BIOSCIENCES INC [US], et al
US 2009068164 A1 20090312 - SEGAL DAVID J [US], et al
US 5420032 A 19950530 - MARSHALL PHILIP [CA], et al
US 6833252 B1 20041221 - DUJON BERNARD [FR], et al
US 6503717 B2 20030107 - CASE CASEY C [US], et al
US 6599692 B1 20030729 - CASE CASEY C [US], et al
US 6607882 B1 20030819 - COX III GEORGE N [US], et al
US 6689558 B2 20040210 - CASE CASEY [US]
US 6824978 B1 20041130 - COX III GEORGE NORBERT [US], et al
US 6933113 B2 20050823 - CASE CASEY C [US]
US 6979539 B2 20051227 - COX III GEORGE NORBERT [US], et al
US 7013219 B2 20060314 - CASE CASEY C [US], et al
US 7163824 B2 20070116 - COX III GEORGE NORBERT [US], et al
US 6008336 A 19991228 - HANSON RICHARD W [US], et al
US 5049386 A 19910917 - EPPSTEIN DEBORAH A [US], et al
US 4946787 A 19900807 - EPPSTEIN DEBORAH A [US], et al
US 4897355 A 19900130 - EPPSTEIN DEBORAH A [US], et al
WO 9117424 A1 19911114 - VICAL INC [US]
WO 9116024 A1 19911031 - VICAL INC [US]
US 4186183 A 19800129 - ALVING CARL R [US], et al
US 4217344 A 19800812 - HANDJANI ROSE-MARIE [FR], et al
US 4235871 A 19801125 - PAPAHADJOPOULOS DEMETRIOS P [US], et al
US 4261975 A 19810414 - FULLERTON W WARDLE, et al
US 4485054 A 19841127 - MEZEI MICHAEL [CA], et al
US 4501728 A 19850226 - GEHO W BLAIR [US], et al
US 4774085 A 19880927 - FIDLER ISAIAH J [US]
US 4837028 A 19890606 - ALLEN THERESA M [CA]
US 9405700 W 19940517
US 4797368 A 19890110 - CARTER BARRIE J [US], et al
WO 9324641 A2 19931209 - US HEALTH [US]
US 5173414 A 19921222 - LEBKOWSKI JANE S [US], et al
US 5928638 A 19990727 - UCHIDA NOBUKO [US], et al
US 2008131962 A1 20080605 - MILLER JEFFREY C [US]
US 2008159996 A1 20080703 - ANDO DALE [US], et al
SCORRANO ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 304, 2003, pages 437 - 444
SAWADA ET AL., NAT. CELL BIOL., vol. 5, 2003, pages 320 - 329
MANDIC ET AL., MOL. CELL BIOL., vol. 21, 2001, pages 3684 - 3691
GRIMES ET AL., PROC. NAT'L. ACOD SCI. USA, vol. 93, 1996, pages 14569 - 14573
ZHANG ET AL., SCIENCE, vol. 290, 2000, pages 989 - 992
SAMBROOK ET AL.: "MOLECULAR CLONING: A LABORATORY MANUAL, 2nd ed.", 1989, COLD SPRING HARBOR LABORATORY PRESS
SAMBROOK ET AL.: "MOLECULAR CLONING: A LABORATORY MANUAL, 3rd ed.", 2001, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL ET AL.: "CURRENT PROTOCOLS IN MOLECULAR BIOLOGY", 1987, JOHN WILEY & SONS
"METHODS IN ENZYMOLOGY", ACADEMIC PRESS
WOLFFC: "CHROMATIN STRUCTURE AND FUNCTION, 3rd ed.", 1998, ACADEMIC PRESS
P.M. WASSARMAN AND A. P. WOLFFE: "METHODS IN ENZYMOLOGY", vol. 304, 1999, ACADEMIC PRESS, article "Chromatin"
P.B. BECKER: "METHODS IN MOLECULAR BIOLOGY", vol. 119, 1999, HUMANA PRESS, article "Chromatin Protocols"
B.D. HAMES AND S.J. HIGGINS: "Nucleic Acid Hybridization: A Practical Approach", 1985, IRL PRESS
B.D. HAMES AND S.J. HIGGINS: "Nucleic Acid Hybridization: A Practical Approach", 1985, IR PRESS
FIELDS ET AL., NATURE, vol. 340, 1989, pages 245 - 246
WINTER ET AL., NATURE, vol. 349, 1991, pages 293 - 299
INBAR ET AL., PROC NATL ACAD SCI USA, vol. 69, 1972, pages 2659 - 2662
EHRLICH ET AL., BIOCHEM, vol. 19, 1980, pages 4091 - 4096
HUSTON ET AL., PROC NATL ACAD SCI USA, vol. 85, 1988, pages 5879 - 5883
PACK ET AL., BIOCHEM, vol. 31, 1992, pages 1579 - 1584
CUMBER ET AL., J IMMUNOLOGY, vol. 149B, 1992, pages 120 - 126
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
VERHOEYAN ET AL., SCIENCE, vol. 239, 1988, pages 1534 - 1536
ROITT I.: "Essential Immunology", 1994, BLACKWELL SCIENTIFIC PUBLICATIONS
JOHN E. COLIGAN ET AL.: "Current Protocols in Immunology", JOHN WILEY & SONS, INC.
BEERLI ET AL., NATURE BIOTECHNOL, vol. 20, 2002, pages 135 - 141
PABO ET AL., ANN. REV. BIOCHEM., vol. 70, 2001, pages 1313 - 340
ISALAN ET AL., NATURE BIOTECHNOL., vol. 19, 2001, pages 656 - 660
SEGAL ET AL., CURR, OPIN. BIOTECHNOL, vol. 12, 2001, pages 632 - 637
CHOO ET AL., CURR. OPIN. STRUCT. BIOL., vol. 10, 2000, pages 411 - 416
"2002-2003 Catalogue, New England Biolabs"
BELFORT ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3379 - 3388
LINN ET AL.: "Nucleases", 1993, COLD SPRING HARBOR LABORATORY PRESS
LI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 4275 - 4279
LI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 2764 - 2768
KIM ET AL., PROC. NATL. CAD. SCI. USA, vol. 91, 1994, pages 883 - 887
KIM ET AL., J BIOL. CHEM., vol. 269, 1994, pages 31,978 - 31,982
BITINAITE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 10,570 - 10,575
ROBERTS ET AL., NUCLEIC ACIDS RES., 2003, pages 418 - 420
DUJON ET AL., GENE, vol. 82, 1989, pages 115 - 118
PERLER ET AL., NUCLEIC ACIDS RES., vol. 22, 1994, pages 1125 - 1127
JASIN, TRENDS GENET., vol. 12, 1996, pages 224 - 228
GIMBLE ET AL., J MOL. BIOL., vol. 263, 1996, pages 163 - 180
ARGAST ET AL., J. MOL. BIOL., vol. 280, 1998, pages 345 - 353
CHEVALIER ET AL., MOLEC. CELL, vol. 10, 2002, pages 895 - 905
EPINAT ET AL., NUCLEIC ACIDS RES., vol. 31, 2003, pages 2952 - 2962
ASHWORTH ET AL., NATURE, vol. 441, 2006, pages 656 - 659
PAQUES ET AL., CURRENT GENE THERAPY, vol. 7, 2007, pages 49 - 66
ANDERSON, SCIENCE, vol. 256, 1992, pages 808 - 913
NABEL; FELGNER, TIBTECH, vol. 11, 1993, pages 211 - 217
MITANI; CASKEY, TIBTECH, vol. 11, January 1999 (1999-01-01), pages 162 - 166
DILLON, TIBTECH, vol. 11, 1993, pages 167 - 175
MILLER, NATURE, vol. 357, 1992, pages 455 - 460
VAN BRUNT, BIOTECHNOLOGY, vol. 6, no. 10, 1988, pages 1149 - 1154
VIGNE, RESTORATIVE NEUROLOGY AND NEUROSCIENCE, vol. 8, 1995, pages 35 - 36
KREMER; PERRICAUDET, BRITISH MEDICAL BULLETIN, vol. 51, no. 1, 1995, pages 31 - 44
DOERFLER AND BÖHM: "Current Topics in Microbiology and Immunology", 1995, article HADDADA ET AL.
YU ET AL., GENE THERAPY, vol. 1, 1994, pages 13 - 26
CRYSTAL, SCIENCE, vol. 270, 1995, pages 404 - 410
BLAESE ET AL., CANCER GENE THER., vol. 2, 1995, pages 291 - 297
BEHR ET AL., BIOCONJUGATE CHEM., vol. 5, 1994, pages 382 - 389
REMY ET AL., BIOCONJUGATE CHEM., vol. 5, 1994, pages 64.7 - 654
GAO ET AL., GENE THERAPY, vol. 2, 1995, pages 710 - 722
AHMAD ET AL., CANCER RES., vol. 52, 1992, pages 4817 - 4820
BUCHSCHER ET AL., J VIROL., vol. 66, 1992, pages 2731 - 2739
JOHANN ET AL., J VIROL., vol. 66, 1992, pages 1635 - 1640
SOMMERFELT ET AL., VIROL., vol. 176, 1990, pages 58 - 59
WILSON ET AL., J. VIROL., vol. 63, 1989, pages 2374 - 2378
MILLER ET AL., J VIROL., vol. 65, 1991, pages 2220 - 2224
WEST ET AL., VIROLOGY, vol. 160, 1987, pages 38 - 47
KOTIN, HUMAN GENE THERAPY, vol. 5, 1994, pages 793 - 801
MUZYCZKA, J CLIN. INVEST., vol. 94, 1994, pages 1351
TRATSCHIN ET AL., MOL. BIOL, vol. 5, 1985, pages 3251 - 3260
TRATSCHIN ET AL., MOL. CELL. BIOL., vol. 4, 1984, pages 2072 - 2081
HERMONAT; MUZYCZKA, PNAS, vol. 81, 1984, pages 6466 - 6470
SAMULSKI ET AL., J. VIROL., vol. 63, pages 03822 - 3 28 989
DUNBAR ET AL., BLOOD, vol. 85, 1995, pages 3048 - 305
KOHN ET AL., NAT. MED., vol. 1, 1995, pages 1017 - 102
MALECH ET AL., PNAS, vol. 94, 1997, pages 22 12133 - 12138
BLAESE ET AL., SCIENCE, vol. 270, 1995, pages 475 - 480
ELLEM ET AL., IMMUNOL IMMUNOTHER., vol. 44, no. 1, 1997, pages 10 - 20
DRANOFF ET AL., HUM. GENE THER., vol. 1, 1997, pages 111 - 2
WAGNER ET AL., LANCET, vol. 351, 1998, pages 9117 1702 - 3
KEARNS ET AL., GENE THER., vol. 9, 1996, pages 748 - 55
STERMAN ET AL., HUM. GENE THER., vol. 7, 1998, pages 1083 - 9
ROSENECKER ET AL., INFECTION, vol. 24, 1996, pages 1 5 - 10
STERMAN ET AL., HUM. GENE THER., vol. 9, 1998, pages 71083 - 0 9
WELSH ET AL., HUM, GENE THER., vol. 2, 1995, pages 205 - 18
ALVAREZ ET AL., GENE THER., vol. 5, 1997, pages 597 - 613
TOPF ET AL., GENE THER., vol. 5, 1998, pages 507 - 513
STERMAN ET AL., HUM. GENE THER., vol. 7, 1998, pages 1083 - 1089
HAN ET AL., PROC. NATL. ACAD SCI. USA, vol. 92, 1995, pages 9747 - 9751
FRESHNEY ET AL.: "Culture of Animal Cells, A Manual of Basic Technique, 3rd ed", 1994
INABA, J. EXP. MED., vol. 176, 1992, pages 1693 - 1702
INABA ET AL., J EXP. MED., vol. 176, 1992, pages 1693 - 1702
ORY ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 11382 - 11388
DULL ET AL., J. VIROL., vol. 72, 1998, pages 8463 - 8471
ZUFFERY ET AL., J VIROL., vol. 72, 1998, pages 9873 - 9880
FOLLENZI ET AL., NATURE GENETICS, vol. 25, 2000, pages 217 - 222
.: "Remington's Pharmaceutical Sciences, 17th ed.", 1989
UMOV ET AL., NATURE, vol. 435, no. 7042, 2005, pages 646 - 651

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2009151591 A2 20091217; WO 2009151591 A3 20100304; AU 2009258117 A1 20091217; AU 2009258117 B2 20141009; CA 2726768 A1 20091217; CA 2726768 C 20160906; CA 2893175 A1 20091217; CA 2893175 C 20160906; EP 2294191 A2 20110316; EP 2294191 A4 20110928; EP 2294191 B1 20160928; EP 2910568 A2 20150826; EP 2910568 A3 20150909; EP 2910568 B1 20180822; HK 1153233 A1 20120323; IL 209716 A0 20110228; IL 209716 A 20141231; IL 224959 A 20141231; JP 2011522564 A 20110804; JP 5763530 B2 20150812; KR 101794638 B1 20171204; KR 101802393 B1 20171128; KR 20110026474 A 20110315; KR 20160113321 A 20160928; US 2010003756 A1 20100107; US 8597912 B2 20131203

DOCDB simple family (application)

US 2009003484 W 20090610; AU 2009258117 A 20090610; CA 2726768 A 20090610; CA 2893175 A 20090610; EP 09762887 A 20090610; EP 15151636 A 20090610; HK 11107397 A 20110715; IL 20971610 A 20101202; IL 22495913 A 20130227; JP 2011513494 A 20090610; KR 20117000526 A 20090610; KR 20167025695 A 20090610; US 45604309 A 20090610