EP 2912179 A1 20150902 - C-MYC ANTISENSE OLIGONUCLEOTIDES AND METHODS FOR USING THE SAME TO TREAT CELL-PROLIFERATIVE DISORDERS
Title (en)
C-MYC ANTISENSE OLIGONUCLEOTIDES AND METHODS FOR USING THE SAME TO TREAT CELL-PROLIFERATIVE DISORDERS
Title (de)
C-MYC-ANTISENSE-OLIGONUKLEOTIDE UND VERFAHREN ZUR VERWENDUNG DAVON ZUR BEHANDLUNG VON AUF DAS ZELLWACHSTUM WIRKENDEN ERKRANKUNGEN
Title (fr)
OLIGONUCLÉOTIDES ANTISENS C-MYC ET SES PROCÉDÉS D'UTILISATION POUR LE TRAITEMENT DE TROUBLES DE LA PROLIFÉRATION CELLULAIRE
Publication
Application
Priority
- US 201261719348 P 20121026
- US 201313829594 A 20130314
- US 201361784910 P 20130314
- US 2013066960 W 20131025
Abstract (en)
[origin: WO2014066851A1] Provided herein are antisense oligonucleotides that can effectively prevent or decrease c-myc protein expression as well as decrease overall rates of cell proliferation in in vitro and mammalian in vivo models of cell proliferative disorders as well as methods for using the same. The antisense oligonucleotides comprise at least one phosphoramidate (NP)-modified or thiophosphoramidate (NPS)-modified intersubunit linkage.
IPC 8 full level
C12N 15/113 (2010.01); A61K 31/7125 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 31/7125 (2013.01); A61P 35/00 (2018.01); C12N 15/1135 (2013.01); C12N 2310/111 (2013.01); C12N 2310/314 (2013.01); C12N 2310/315 (2013.01); C12N 2310/345 (2013.01); C12N 2310/3515 (2013.01); C12N 2310/3517 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2014066851 A1 20140501; CA 2887702 A1 20140501; CA 2887702 C 20230801; CA 3201145 A1 20140501; EP 2912179 A1 20150902; EP 2912179 A4 20161012; HK 1214293 A1 20160722
DOCDB simple family (application)
US 2013066960 W 20131025; CA 2887702 A 20131025; CA 3201145 A 20131025; EP 13849097 A 20131025; HK 16102007 A 20160223