EP 2928909 B1 20180801 - AN AMPHIPATHIC PEPTIDE
Title (en)
AN AMPHIPATHIC PEPTIDE
Title (de)
AMPHIPATISCHES PEPTID
Title (fr)
PEPTIDE AMPHIPATHIQUE
Publication
Application
Priority
- GB 201222041 A 20121207
- EP 2013075985 W 20131209
Abstract (en)
[origin: WO2014087023A1] The present invention is directed to an amphipathic peptide and methods of using the amphipathic peptide for delivering small molecule agents to a cell. Ideally, the amphipathic cell penetrating peptide comprises less than approximately 50 amino acid residues with at least 6 arginine residues, at least 12 Alanine Residues, at least 6 leucine resiues, optionally at least one cysteine residue, and at least two but no greater than three glutamic acids wherein the arginine residues are evenly distributed along the length of the peptide; and the peptide has a defined ratio of arginine to negatively charged amino acid residues and a defined ratio of hydrophilic amino acid residues to hydrophobic amino acid residues. The present invention is also directed to a nanoparticle and cell del ivery system comprising the amph ipathic cell penetrating peptide of the invention. The peptide, nanoparticle or cell delivery system of the invention may be used in therapy. For example, the peptide may be used as a therapeutic agent delivery system, in which the therapeutic agent may include nucleic acids or other small molecules.
IPC 8 full level
C07K 14/00 (2006.01); A61K 33/242 (2019.01); A61K 48/00 (2006.01)
CPC (source: EP US)
A61K 31/713 (2013.01 - EP US); A61K 33/242 (2018.12 - EP US); A61K 33/42 (2013.01 - EP US); A61K 38/44 (2013.01 - EP US); A61K 47/60 (2017.07 - EP US); A61K 47/64 (2017.07 - EP US); A61K 47/6455 (2017.07 - US); A61K 47/6929 (2017.07 - EP US); A61K 48/0025 (2013.01 - US); C07K 7/08 (2013.01 - EP US); C07K 14/00 (2013.01 - EP US); C07K 14/001 (2013.01 - US); C12N 15/113 (2013.01 - US); C12N 15/87 (2013.01 - EP US); C07K 2319/00 (2013.01 - US); C07K 2319/09 (2013.01 - EP US); C07K 2319/10 (2013.01 - EP US); C07K 2319/33 (2013.01 - EP US); C12N 2310/14 (2013.01 - US); C12N 2310/3513 (2013.01 - US); C12N 2320/32 (2013.01 - US); C12Y 114/13039 (2013.01 - EP US)
Citation (examination)
MCCARTHY HELEN O ET AL: "Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery", JOURNAL OF CONTROLLED RELEASE, vol. 189, 10 September 2014 (2014-09-10), pages 141 - 149, ISSN: 0168-3659(print)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2014087023 A1 20140612; DK 2928909 T3 20181119; DK 3415525 T3 20220214; EP 2928909 A1 20151014; EP 2928909 B1 20180801; EP 3415525 A1 20181219; EP 3415525 B1 20220105; EP 4008724 A1 20220608; ES 2693163 T3 20181207; ES 2906907 T3 20220420; HU E058783 T2 20220928; PL 3415525 T3 20220404; US 10188744 B2 20190129; US 10500287 B2 20191210; US 2015314011 A1 20151105; US 2018043031 A1 20180215; US 2019091344 A1 20190328; US 9744244 B2 20170829
DOCDB simple family (application)
EP 2013075985 W 20131209; DK 13805332 T 20131209; DK 18186186 T 20131209; EP 13805332 A 20131209; EP 18186186 A 20131209; EP 21211053 A 20131209; ES 13805332 T 20131209; ES 18186186 T 20131209; HU E18186186 A 20131209; PL 18186186 T 20131209; US 201314649606 A 20131209; US 201715688484 A 20170828; US 201816215183 A 20181210