EP 2938626 A1 20151104 - SELF-ASSEMBLED ULTRASHORT PEPTIDES HYDROGELS FOR WOUND HEALING, SKIN CARE AND COSMETICS APPLICATIONS
Title (en)
SELF-ASSEMBLED ULTRASHORT PEPTIDES HYDROGELS FOR WOUND HEALING, SKIN CARE AND COSMETICS APPLICATIONS
Title (de)
SELBSTANORDNENDE ULTRAKURZE PEPTIDHYDROGELE FÜR WUNDHEILUNGS-, HAUTPFLEGE- UND KOSMETIKANWENDUNGEN
Title (fr)
HYDROGELS PEPTIDIQUES ULTRACOURTS AUTO-ASSEMBLÉS POUR CICATRISATION DE PLAIES, SOINS DE LA PEAU ET APPLICATIONS COSMÉTIQUES
Publication
Application
Priority
- SG 2012096699 A 20121231
- SG 2013000564 W 20131231
Abstract (en)
[origin: WO2014104981A1] The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hydrogel that includes the amphiphilic linear peptide/peptoid. The amphiphilic linear peptide/peptoid is capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water, and forming a hydrogel. These peptides/peptoids include short amphiphilic sequences with a hydrophobic portion of aliphatic amino acids and at least one acidic, neutral, or basic polar amino acid. The amphiphilic linear peptide/peptoid is build up of non repetitive aliphatic amino acids, which may be in the L- or D-form. A plurality of such peptides/peptoids assembles to supramolecular helical fibers and forms peptide hydrogels after assembly. A corresponding hydrogel is formed in aqueous solutions at physiological pH and is thus useful for inter alia cell culture, tissue engineering, tissue regeneration, wound healing and release of bioactive moieties (including cells, nucleic acids, anti-microbials, micro-/nanoparticles, cosmetic agents and small molecule therapeutics), as well as for providing mechanical support for damaged or missing tissues. Such hydrogels can also be formed in situ, wherein the gelation process occurs within the body following the injection of a peptide solution. Such hydrogels, which are rigid, biocompatible and entrap up to 99.9% of water, are also well suited for applications utilizing electronic devices.
IPC 8 full level
A61K 38/06 (2006.01); A61K 38/07 (2006.01); A61K 38/08 (2006.01); A61K 47/42 (2006.01); C07K 5/062 (2006.01); C07K 5/083 (2006.01); C07K 5/103 (2006.01); C07K 7/06 (2006.01)
CPC (source: EP)
C07K 5/06026 (2013.01); C07K 5/06034 (2013.01); C07K 5/0806 (2013.01); C07K 5/0808 (2013.01); C07K 5/1008 (2013.01); C07K 5/101 (2013.01); C07K 7/06 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2014104981 A1 20140703; CN 105189532 A 20151223; CN 105189532 B 20201103; EP 2938626 A1 20151104; EP 2938626 A4 20160817; SG 11201505160P A 20150730; SG 2012096699 A 20140730
DOCDB simple family (application)
SG 2013000564 W 20131231; CN 201380074051 A 20131231; EP 13869801 A 20131231; SG 11201505160P A 20131231; SG 2012096699 A 20121231