EP 2940017 A3 20160217 - PROCESSES FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
Title (en)
PROCESSES FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
Title (de)
Verfahren zur Herstellung von als Hemmer der ATR-Kinase nützlichen Verbindungen
Title (fr)
Processus de préparation de composés utiles en tant qu'inhibiteurs de kinase d'ATR
Publication
Application
Priority
- US 201161541865 P 20110930
- EP 12772856 A 20120928
- US 2012058127 W 20120928
Abstract (en)
[origin: WO2013049726A2] The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula (I) or (II) wherein the variables are as defined herein.
IPC 8 full level
C07D 413/04 (2006.01); A61K 31/497 (2006.01); A61P 35/00 (2006.01)
CPC (source: CN EP IL KR RU US)
A61K 31/497 (2013.01 - KR RU); A61P 35/00 (2017.12 - KR RU); C07B 59/00 (2013.01 - CN); C07C 251/48 (2013.01 - IL KR US); C07C 269/06 (2013.01 - CN); C07D 241/20 (2013.01 - CN IL KR US); C07D 309/14 (2013.01 - CN); C07D 413/04 (2013.01 - CN EP IL KR RU US); C07D 413/14 (2013.01 - CN IL KR RU US); C07B 2200/05 (2013.01 - CN); Y02P 20/55 (2015.11 - EP)
C-Set (source: CN)
Citation (search report)
- [Y] WO 2010071837 A1 20100624 - VERTEX PHARMA [US], et al
- [Y] WO 2008122375 A2 20081016 - BAYER CROPSCIENCE AG [DE], et al
- [YP] WO 2011143422 A1 20111117 - VERTEX PHARMA [US], et al
- [AP] WO 2011124998 A1 20111013 - PFIZER [US], et al
- [Y] HILFIKER R (EDITOR) ED - HILFIKER R: "Polymorphism in the Pharmaceutical Industry", 1 January 2006, 20060101, PAGE(S) 1 - 19, ISBN: 978-3-527-31146-0, XP002528052
- [Y] CAIRA: "Crystalline Polymorphism of Organic Compounds", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 198, 1 January 1998 (1998-01-01), pages 163 - 208, XP008166276, ISSN: 0340-1022
- [Y] GENTILI F ET AL: "Alpha2-Adrenoreceptors Profile Modulation. 4. From Antagonist to Agonsit Behaviour", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 51, no. 14, 25 June 2008 (2008-06-25), pages 4289 - 4299, XP002557308, ISSN: 0022-2623, DOI: 10.1021/JM800250Z
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
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DOCDB simple family (application)
US 2012058127 W 20120928; AR P120103661 A 20121001; AU 2012315615 A 20120928; AU 2017206213 A 20170720; AU 2019210688 A 20190805; BR 112014007721 A 20120928; CA 2850566 A 20120928; CA 3124539 A 20120928; CN 201280055772 A 20120928; CN 201610803752 A 20120928; EP 12772856 A 20120928; EP 15151822 A 20120928; EP 19192826 A 20120928; EP 21169893 A 20120928; ES 15151822 T 20120928; HK 15101674 A 20150213; HK 16104989 A 20160430; HR P20191641 T 20190912; HU E15151822 A 20120928; IL 23177114 A 20140327; IL 26545919 A 20190319; IL 28484921 A 20210714; IN 929KON2014 A 20140428; JP 2014533441 A 20120928; JP 2016221714 A 20161114; JP 2017148280 A 20170731; JP 2019099224 A 20190528; KR 20147011924 A 20120928; KR 20197023926 A 20120928; MX 2014003794 A 20120928; NZ 62308912 A 20120928; NZ 71912212 A 20120928; NZ 73709012 A 20120928; PL 15151822 T 20120928; PT 15151822 T 20120928; RS P20191197 A 20120928; RU 2014117635 A 20120928; RU 2018147217 A 20120928; SG 10201606774U A 20120928; SG 11201401093W A 20120928; TW 101136270 A 20121001; TW 106110597 A 20121001; TW 107102422 A 20121001; US 201213631759 A 20120928; US 201514678489 A 20150403; US 201715849241 A 20171220; US 201816233641 A 20181227; ZA 201402625 A 20140410