EP 2943182 A1 20151118 - GALENIC FORM FOR THE ADMINISTRATION OF AN ACTIVE INGREDIENT
Title (en)
GALENIC FORM FOR THE ADMINISTRATION OF AN ACTIVE INGREDIENT
Title (de)
GALENISCHE FORM ZUR VERABREICHUNG EINES WIRKSTOFFS
Title (fr)
FORME GALENIQUE POUR L'ADMINISTRATION D'UN PRINCIPE ACTIF
Publication
Application
Priority
- FR 1350308 A 20130114
- FR 2014050070 W 20140114
Abstract (en)
[origin: WO2014108657A1] Galenic form for the oral transmucosal administration of an active ingredient for accelerated induction of sleep and/or the treatment of sleep disorders and/or the treatment of a central nervous system attack, wherein said active ingredient is lipophilic or amphiphilic and is in a state of stable and complete dissolution in an aqueous-alcoholic solution comprising between 35% and 70% by weight of ethanol and between 30% and 65% by weight of water, generating, in this aqueous-alcoholic solution, the formation of nanostructures of said active ingredient under consideration, facilitating the crossing of the blood-brain barrier by said active ingredient, wherein said active ingredient is in base and/or salt form and belongs to the chemical families of sleep inducers or modulators of lipophilic or amphiphilic nature and having a molecular weight of less than 1000 daltons, wherein said active ingredient is chosen from the imidazopyridine family, comprising zolpidem, the cyclopyrrolone family, comprising eszopiclone, the pyrazolopyrimidine family, comprising zaleplon, the benzodiazepine family, comprising midazolam and brotizolam, the H1 antihistamine sedative family, comprising doxylamine and cyproheptadine, and/or the melatonin and melatonin agonist family, comprising melatonin, ramelteon and agomelatine, wherein the volume of said aqueous-alcoholic solution is less than or equal to 2 ml and said active ingredient is present at a dose of less than or equal to 8 mg, all of said active ingredient being absorbed transmucosally through the mucosae of the floor of the oral cavity, in particular the gingivo-jugal, para-gingival, jugal or sublingual mucosae.
IPC 8 full level
A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 31/437 (2006.01); A61K 31/4745 (2006.01); A61K 47/10 (2006.01)
CPC (source: EP US)
A61K 9/006 (2013.01 - EP US); A61K 9/08 (2013.01 - EP US); A61K 31/165 (2013.01 - EP US); A61K 31/343 (2013.01 - EP US); A61K 31/352 (2013.01 - EP US); A61K 31/4045 (2013.01 - EP US); A61K 31/437 (2013.01 - EP US); A61K 31/4402 (2013.01 - EP US); A61K 31/451 (2013.01 - EP US); A61K 31/4985 (2013.01 - EP US); A61K 31/519 (2013.01 - EP US); A61K 31/551 (2013.01 - EP US); A61K 31/5517 (2013.01 - EP US); A61K 47/10 (2013.01 - EP US); A61P 25/00 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/20 (2017.12 - EP)
Citation (search report)
See references of WO 2014108657A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2014108657 A1 20140717; BR 112015016869 A2 20170711; CA 2897685 A1 20140717; CN 105025880 A 20151104; EP 2943182 A1 20151118; FR 3000896 A1 20140718; FR 3000896 B1 20160826; JP 2016504405 A 20160212; MX 2015009027 A 20160120; RU 2015134148 A 20170216; US 2015352038 A1 20151210
DOCDB simple family (application)
FR 2014050070 W 20140114; BR 112015016869 A 20140114; CA 2897685 A 20140114; CN 201480011684 A 20140114; EP 14703148 A 20140114; FR 1350308 A 20130114; JP 2015552133 A 20140114; MX 2015009027 A 20140114; RU 2015134148 A 20140114; US 201414759822 A 20140114